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The contribution of geogenic particulate matter to lung disease in indigenous children

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Shepherd, CCJ, Clifford, HD, Mitrou, F, Melody, SM ORCID: 0000-0002-6692-739X, Bennett, EJ ORCID: 0000-0002-9818-827X, Johnston, FH ORCID: 0000-0002-5150-8678, Knibbs, LD, Pereira, G, Pickering, JL, Teo, TH, Kirkham, LS, Thornton, RB, Kicic, A, Ling, K-M, Alach, Z, Lester, M, Franklin, P, Reid, D and Zosky, GR ORCID: 0000-0001-9039-0302 2019 , 'The contribution of geogenic particulate matter to lung disease in indigenous children' , International Journal of Environmental Research and Public Health, vol. 16, no. 15 , pp. 1-12 , doi: 10.3390/ijerph16152636.

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Abstract

Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02-3.06]) and lower (OR 1.99 95% CI [1.08-3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20-7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high.

Item Type: Article
Authors/Creators:Shepherd, CCJ and Clifford, HD and Mitrou, F and Melody, SM and Bennett, EJ and Johnston, FH and Knibbs, LD and Pereira, G and Pickering, JL and Teo, TH and Kirkham, LS and Thornton, RB and Kicic, A and Ling, K-M and Alach, Z and Lester, M and Franklin, P and Reid, D and Zosky, GR
Keywords: indigenous health, geogenic PM, indigenous, bacterial infection, child health, geogenic, particulate matter
Journal or Publication Title: International Journal of Environmental Research and Public Health
Publisher: M D P I AG
ISSN: 1661-7827
DOI / ID Number: 10.3390/ijerph16152636
Copyright Information:

Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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