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An automated algorithm for the detection of cortical interruptions and its underlying loss of trabecular bone; A reproducibility study
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Abstract
Background:We developed a semi-automated algorithm that detects cortical interruptions in finger joints using high-resolution peripheral quantitative computed tomography (HR-pQCT), and extended it with trabecular void volume measurement. In this study we tested the reproducibility of the algorithm using scan/re-scan data.Methods:Second and third metacarpophalangeal joints of 21 subjects (mean age 49 (SD 11) years, 17 early rheumatoid arthritis and 4 undifferentiated arthritis, all diagnosed SD).Results:Per joint, the mean number of interruptions was 3.1 (SD 3.6), mean interruption surface 4.2 (SD 7.2) mm2, and mean interruption volume 3.5 (SD 10.6) mm3 for OP1. Intra- and inter-operator reliability was excellent for the cortical interruption parameters (ICC ≥0.91), except good for the inter-operator reliability of the interruption surface (ICC = 0.70). The LSCSD per joint was 4.2 for the number of interruptions, 5.8 mm2 for interruption surface, and 3.2 mm3 for interruption volume.Conclusions:The algorithm was highly reproducible in the detection of cortical interruptions and their volume. Based on the LSC findings, the potential value of this algorithm for monitoring structural damage in the joints in early arthritis patients needs to be tested in clinical studies.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Peters, M and de Jong, J and Scharmga, A and van Tubergen, A and Geusens, P and Loeffen, D and Weijers, R and Boyd, SK and Barnabe, C and Stok, KS and van Rietbergen, B and van den Bergh, J |
| Keywords: | bone micro-architecture, cortical interruptions, high resolution peripheral quantitative computed tomography, image processing, precision, rheumatoid arthritis |
| Journal or Publication Title: | BMC Medical Imaging |
| Publisher: | BioMed Central Ltd. |
| ISSN: | 1471-2342 |
| DOI / ID Number: | https://doi.org/10.1186/s12880-018-0255-7 |
| Copyright Information: | Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ |
| Item Statistics: | View statistics for this item |
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