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Factors associated with first-line antiretroviral treatment failure in adult HIV-positive patients: A case-control study from Ethiopia

Bezabih, YM, Beyene, F and Bezabhe, WM ORCID: 0000-0002-3028-6949 2019 , 'Factors associated with first-line antiretroviral treatment failure in adult HIV-positive patients: A case-control study from Ethiopia' , BMC Infectious Diseases, vol. 19, no. 1 , pp. 1-8 , doi:

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Background:Treatment failure has become a significant challenge in patients taking antiretroviral therapy (ART). The aim of the present study was to identify risk factors for first-line ART failure among patients attending clinical follow-up.Methods:A 1:2 matched case-control study (by age, sex, and treatment duration since initiated on ART) was conducted from June 2015 to July 2017 on adult patients (aged ≥15 years) who were on ART for at least 6 months. Cases were selected from patients who were switched to second-line ART after first-line ART failure (viral load ≥1000 copies/mL). Controls were randomly selected from patients on first-line ART with viral load Results:Of the 273 patients who participated in this study, 55% were males. Ninety-one cases were compared with 182 controls. The median age of participants was 40 years and the median duration of treatment since initiated on ART was 69 months. Independent risk factors associated with first-line antiretroviral treatment failure were discontinuation of ART (adjusted odds ratio (AOR) = 9.8, 95% confidence interval (CI): 4.0–23.8), baseline CD4 lymphocyte count ≤50 cells/mm3 (AOR = 3.8, 95% CI: 1.5–9.6) and persistent diarrhea (AOR = 4.4, 95% CI: 1.5–13.2). The risk of ART failure was high and comparable whether the duration of ART discontinuation was greater or less than 1 month (crude odds ratio (COR) = 6.3 and 8. 5 respectively, p-value Conclusions:Our findings underscore the importance of avoiding ART discontinuation of any duration, early initiation of ART and diarrhea management to prevent first-line ART failure.

Item Type: Article
Authors/Creators:Bezabih, YM and Beyene, F and Bezabhe, WM
Keywords: virologic failure, Antiretroviral, case-control, HIV, AIDS, Ethiopia
Journal or Publication Title: BMC Infectious Diseases
Publisher: Biomed Central Ltd
ISSN: 1471-2334
DOI / ID Number:
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Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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