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Macroporous monolith supports for continuous flow capillary microreactors


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Bolton, KF, Canty, AJ, Deverell, JA, Guijt, RM, Hilder, EF, Rodemann, T and Smith, JA 2006 , 'Macroporous monolith supports for continuous flow capillary microreactors' , Tetrahedron Letters, vol. 47, no. 52 , pp. 9321-9324 , doi: 10.1016/j.tetlet.2006.10.113.

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A solid macroporous monolith is shown to be a suitable substrate for anchoring a palladium complex to obtain a continuous porous material suitable for conducting flow-through catalysis in capillary microreactors. The monolith for this study was GMA-co-EDMA [poly(glycidyl
methacrylate-co-ethylene dimethacrylate)] in fused silica capillaries (250 micrometre internal diameter). Immobilisation of ligand was achieved by passing a solution of 5-hydroxy-1,10-phenanthroline, and palladium(II) was added. Suzuki-Miyaura catalysis was studied. The excellent flow-through properties, firm attachment
to capillary walls, and robustness of the capillary systems
for catalysis demonstrated after continuous reaction for four days indicate that this approach is suitable for further development of capillary-based microreactors that are suitable for continuous flow processes and parallel synthesis.

Item Type: Article
Authors/Creators:Bolton, KF and Canty, AJ and Deverell, JA and Guijt, RM and Hilder, EF and Rodemann, T and Smith, JA
Journal or Publication Title: Tetrahedron Letters
ISSN: 0040-4039
DOI / ID Number: 10.1016/j.tetlet.2006.10.113
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