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Second courses of transcranial magnetic stimulation (TMS) in major depressive episodes for initial responders and non-responders


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Pridmore, S ORCID: 0000-0002-9170-1798, Erger, S and May, T 2019 , 'Second courses of transcranial magnetic stimulation (TMS) in major depressive episodes for initial responders and non-responders' , Malaysian Journal of Medical Sciences, vol. 26, no. 3 , pp. 102-109 , doi: 10.21315/mjms2019.26.3.8.

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Background:Transcranial Magnetic Stimulation (TMS) is effective in major depressive episodes (MDE). However, MDE may follow a chronic, relapsing course, and some individuals may not satisfactorily respond to a first course of TMS.Objective:To investigate the outcome of second courses of TMS.Method:A naturalistic investigation—we prospectively studied 30 MDE in-patients and routinely collected information, including pre- and post-treatment with Six-item Hamilton Depression Rating Scale (HAMD6), a six-item Visual Analogue Scale (VAS6) and the Clinical Global Impression-Severity (CGI-S). Two categories of patients were considered: i) those who had remitted with a first course, but relapsed, and ii) those who had not remitted with the first course.Results:Thirty individuals received a second TMS course. The mean time to the second course was 27.5 weeks. Based on the HAMD6, 26 (87%) achieved remission after the first course, and 22 (73%) achieved remission after the second course. Furthermore, based on the HAMD6 results, of the four patients who did not achieve remission with a first course, three (75%) did so with a second course.Conclusion:In MDE, a second course of TMS is likely to help those who remitted to a first course and then relapsed, as well as those who did not achieve remission with a first course.

Item Type: Article
Authors/Creators:Pridmore, S and Erger, S and May, T
Keywords: transcranial magnetic stimulation, depression, neurostimulation
Journal or Publication Title: Malaysian Journal of Medical Sciences
Publisher: Universiti Sains Malaysia, School of Medical Sciences
ISSN: 1394-195X
DOI / ID Number: 10.21315/mjms2019.26.3.8
Copyright Information:

Copyright 2019 Penerbit Universiti Sains Malaysia. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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