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Elevated circulating IL-17 level is associated with inflammatory arthritis and disease activity: A meta-analysis

Zhang, X, Yuan, Y, Pan, Z, Ma, Y, Wu, M, Yang, J, Han, R, Chen, M, Hu, X, Liu, R, Sam, NB, Xu, S and Pan, F 2019 , 'Elevated circulating IL-17 level is associated with inflammatory arthritis and disease activity: A meta-analysis' , Clinica Chimica Acta, vol. 496 , pp. 76-83 , doi: 10.1016/j.cca.2019.06.026.

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Objectives: Previous studies found that the interleukin (IL)-17 level was elevated in inflammatory arthritis, but results were inconsistent. This meta-analysis aimed to investigate the association of IL-17 cytokine with osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA).Methods: Relevant studies were searched using databases. Standardized mean difference (SMD) was calculated. Correlation coefficient was utilized to evaluate the relationship between IL-17 and disease activity of AS and RA. Subgroup analysis, sensitivity analysis and meta-regression were applied to explore the sources of heterogeneity.Results: 83 records were enrolled. The IL-17 level was elevated in AS (SMD = 2.348, P P P P = .016), and similar results occurred in subgroup analysis. Furthermore, the IL-17 level was positively associated with disease activity of AS and RA.Conclusion: Circulating IL-17 level is significantly elevated in inflammatory arthritis and is related to the disease activity of AS and RA, suggesting that it plays an important role in the pathogenesis and progression of inflammatory arthritis (especially in AS and RA).

Item Type: Article
Authors/Creators:Zhang, X and Yuan, Y and Pan, Z and Ma, Y and Wu, M and Yang, J and Han, R and Chen, M and Hu, X and Liu, R and Sam, NB and Xu, S and Pan, F
Keywords: arthritis, cytokines, IL-17, inflammatory arthritis, interleukin-17
Journal or Publication Title: Clinica Chimica Acta
Publisher: Elsevier Science Bv
ISSN: 0009-8981
DOI / ID Number: 10.1016/j.cca.2019.06.026
Copyright Information:

© 2019 Elsevier B.V. All rights reserved.

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