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Abstract

Background: During a pertussis epidemic in 2009, the Department of Health, Victoria, Australia, implemented a cocoon program offering parents of new babies a funded-dose of pertussis-containing vaccine.We assessed vaccine effectiveness (VE) of the program in reducing pertussis infection in infants.Methods: Using a matched case-control design, infants aged Results: The study recruited 215 cases and 240 controls (response rates 67% and 25% of eligible participants,respectively). Vaccination of both parents after delivery of the infant and 28 days prior to illness onset reduced pertussis infection by 77% (Vaccine Effectiveness [VE] = 77% (confidence interval [95% CI],18-93%). After adjusting for maternal education, presence of a sibling within the household, and the infants' primary course vaccination status, the adjusted VE was 64% (95% CI, -58-92%).Conclusions: Although not reaching statistical significance, our results demonstrated that cocoon immunisation - where both parents are vaccinated in the post-partum period – may offer some protection again infant pertussis infection. Cocoon immunisation could be considered in circumstances where antenatal vaccination of the mother has not occurred.

Item Type:	Article
Authors/Creators:	Rowe, SL and Tay, EL and Franklin, LJ and Stephens, N and Ware, RS and Kaczmarek, MC and Lester, RA
Keywords:	pertussis, cocoon, immunization, vaccine, vaccination, infant
Journal or Publication Title:	Vaccine
Publisher:	Elsevier Sci Ltd
ISSN:	0264-410X
DOI / ID Number:	https://doi.org/10.1016/j.vaccine.2018.02.094
Copyright Information:	Crown Copyright 2018 Published by Elsevier Ltd. All rights reserved.
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