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Abstract

Background: The factors influencing the severity of apnea-related hypoxemia and bradycardia are incompletely characterized, especially in infants receiving noninvasive respiratory support.Objectives: To identify the frequency and predictors of physiological instability (hypoxemia-oxygen saturation (SpO2) Methods: Respiratory pause duration, derived from capsule pneumography, was measured in 30 preterm infants of gestation 30 (24-32) weeks [median (interquartile range)] receiving noninvasive respiratory support and supplemental oxygen. For identified pauses of 5 to 29 seconds duration, we measured the magnitude and duration of SpO2 and HR reductions over a period starting at the pause onset and ending 60 seconds after resumption of breathing. Temporally clustered pauses (Results: In total, 17 105 isolated and 9180 clustered pauses were identified. Hypoxemia and bradycardia were more likely after longer duration and temporally-clustered pauses. However, the majority of such episodes occurred after 5 to 9 second pauses given their numerical preponderance, and short-lived pauses made a substantial contribution to physiological instability overall. Birth gestation, hemoglobin concentration, form of respiratory support, caffeine treatment, respiratory pause duration and temporal clustering were identified as predictors of instability.Conclusions: Brief respiratory pauses, especially when clustered, contribute substantially to hypoxemia and bradycardia in preterm infants.

Item Type:	Article
Authors/Creators:	Marshall, AP and Lim, K and Ali, SK and Gale, TJ and Dargaville, PA
Keywords:	apnea, bradycardia, hyperoxemia, hypoxemia
Journal or Publication Title:	Pediatric Pulmonology
Publisher:	Wiley-Liss
ISSN:	8755-6863
DOI / ID Number:	https://doi.org/10.1002/ppul.24451
Copyright Information:	Copyright 2019 Wiley Periodicals, Inc.
Related URLs:	Google Scholar: Gale, TJ UTAS Profile: Gale, TJ UTAS Profile: Dargaville, PA
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