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Abstract

Background and objective:Long‐term respiratory risks following exposure to relatively short periods of poor air quality early in life are unknown. We aimed to evaluate the association between exposure to a 6‐week episode of air pollution from a coal mine fire in children aged Methods: We conducted a prospective cohort study. Individual exposure to 24‐h average and peak concentrations of particulate matter with an aerodynamic diameter 2.5) during the fire were estimated using dispersion and chemical transport modelling. Lung function was measured using the forced oscillation technique (FOT), generating standardized Z‐scores for resistance and reactance at a frequency of 5 Hz (Rrs5 and Xrs5), and area under the reactance curve (AX). We used linear regression models to assess the associations between PM2.5 exposure and lung function, adjusted for potential confounders. Results:Of the 203 infants originally recruited, 84 aged 4.3 ± 0.5 years completed FOT testing. Median (interquartile range, IQR) for average and peak PM2.5 were 7.9 (6.8-16.8) and 103.4 (60.6-150.7) μg/m3, respectively. The mean ± SD Z‐scores for Rrs5, Xrs5 and AX were 0.56 ± 0.80, -0.76 ± 0.88 and 0.72 ± 0.92, respectively. After adjustment for potential confounders including maternal smoking during pregnancy, a 10 μg/m3 increase in average PM2.5 was significantly associated with worsening AX (β‐coefficient: 0.260; 95% CI: 0.019, 0.502), while the association between a 100‐μg/m3 increase in peak PM2.5 and AX was borderline (0.166; 95% CI: -0.002, 0.334).Conclusion:Infant exposure to coal mine fire emissions could be associated with long‐term impairment of lung reactance.

Item Type:	Article
Authors/Creators:	Shao, J and Zosky, GR and Hall, GL and Wheeler, AJ and Dharmage, S and Melody, S and Dalton, M and Foong, RE and O'Sullivan, T and Williamson, G and Chappell, K and Abramson, MJ and Johnston, FH
Keywords:	long-term effects, outdoor smoke, particulate matter, preschool children, respiratory function tests, coal
Journal or Publication Title:	Respirology
Publisher:	Blackwell Publishing Asia
ISSN:	1323-7799
DOI / ID Number:	10.1111/resp.13617
Copyright Information:	© 2019 Asian Pacific Society of Respirology
Related URLs:	Google Scholar: Zosky, GR UTAS Profile: Zosky, GR Google Scholar: Wheeler, AJ UTAS Profile: Melody, S Google Scholar: Williamson, G UTAS Profile: Williamson, G Google Scholar: Johnston, FH UTAS Profile: Johnston, FH
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