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Abstract

Objective: The aim was to investigate the potential association between hearing impairment and incident depressive symptoms.Methods: Using a prospective community-based cohort study in France (the Paris Prospective Study III), participants aged 50-75 years were recruited between 2008 and 2012 and thereafter followed up every 2 years up to 2018. Hearing impairment, measured at study recruitment by audiometry testing, was defined as a pure tone average >25 decibels in the better ear. Incident depressive symptoms, measured using the validated 13-item Questionnaire of Depression 2nd version, was assessed during follow-up. Multivariate generalized estimating equations were used to compute odds ratio (OR) and 95% confidence intervals (CI).Results: Among 7591 participants free of depressive symptoms at baseline (mean age 59.8 years, 63% of men), 14.3% had hearing impairment. Over 6 years of follow-up, 479 subjects (6.3%) had incident depressive symptoms. The OR for incident depressive symptoms was 1.36 for subjects with baseline hearing impairment (95% CI, 1.06-1.73). A pooled analysis of 4 published prospective studies yielded a multivariable relative risk of baseline hearing impairment for incident depressive symptoms of 1.29 (95% CI, 1.09-1.53).Conclusions: In this community-based prospective cohort study of participants aged 50 to 75 years, baseline hearing impairment was associated with a 36% increased odds of incident depressive symptoms.

Item Type:	Article
Authors/Creators:	Lisan, Q and van Sloten, TT and Lemogne, C and Offredo, L and Climie, RE and Boutouyrie, P and Guibout, C and Thomas, F and Danchin, N and Jouven, X and Empana, J-P
Keywords:	cohort study, depressive symptoms, hearing impairment, prospective
Journal or Publication Title:	American Journal of Medicine
Publisher:	Excerpta Medica Inc
ISSN:	0002-9343
DOI / ID Number:	https://doi.org/10.1016/j.amjmed.2019.05.039
Copyright Information:	© 2019 Elsevier Inc. All rights reserved.
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