Open Access Repository

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

Downloads

Downloads per month over past year

Brown, LS, Foster, CG, Courtney, JM ORCID: 0000-0003-4461-4197, King, NE, Howells, DW ORCID: 0000-0002-2512-7724 and Sutherland, BA ORCID: 0000-0002-0791-0950 2019 , 'Pericytes and Neurovascular Function in the Healthy and Diseased Brain' , Frontiers in cellular neuroscience , pp. 1-9 , doi: 10.3389/fncel.2019.00282.

[img]
Preview
PDF
Brown et al 201...pdf | Download (1MB)

| Preview

Abstract

Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit (NVU), a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both in vitro and in vivo will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer's disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future.

Item Type: Article
Authors/Creators:Brown, LS and Foster, CG and Courtney, JM and King, NE and Howells, DW and Sutherland, BA
Keywords: cerebral blood flow, pericyte, central nervous system, disease, capillary, brain, neurovascular, neurological disease, cerebral blood flow, blood brain barrier
Journal or Publication Title: Frontiers in cellular neuroscience
Publisher: Frontiers Research Foundation
ISSN: 1662-5102
DOI / ID Number: 10.3389/fncel.2019.00282
Copyright Information:

Copyright 2019 Brown, Foster, Courtney, King, Howells and Sutherland. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP