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Effects of Intermittent Versus Continuous Energy Intakes on Insulin Sensitivity and Metabolic Risk in Women with Overweight

Hutchison, AT, Liu, B, Wood, RE ORCID: 0000-0001-7053-6319, Vincent, AD, Thompson, CH, O'Callaghan, NJ, Wittert, GA and Heilbronn, LK 2019 , 'Effects of Intermittent Versus Continuous Energy Intakes on Insulin Sensitivity and Metabolic Risk in Women with Overweight' , Obesity, vol. 27, no. 1 , pp. 50-58 , doi:

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Objective: This study aimed to compare intermittent fasting (IF) versus continuous energy intakes at 100%or 70% of calculated energy requirements on insulin sensitivity, cardiometabolic risk, body weight, andcomposition.Methods: Women with overweight (n=88; 50±1 years, BMI 32.3±0.5 kg/m2) were randomized to one offour diets (IF70, IF100, dietary restriction [DR70], or control) in a 2:2:2:1 ratio for 8 weeks. IF groups fastedfor 24 hours after breakfast on three nonconsecutive days per week. All foods were provided and dietsmatched for macronutrient composition (35% fat, 15% protein, 50% carbohydrate). Insulin sensitivity byhyperinsulinemic-euglycemic clamp, weight, body composition, and plasma markers were assessed following a “fed” day (12-hour fast) and a 24-hour fast (IF only).Results: displayed greater reductions in weight, fat mass, total- and low-density lipoprotein cholesterol, and nonesterified fatty acids compared with DR70 and IF100 (all P≤0.05). IF100 lost more weight andfat than control. However, fasting insulin was increased. There were no group differences in insulin sensitivity by clamp; however, a 24-hour fast transiently reduced insulin sensitivity.Conclusions: When prescribed at matched energy restriction, IF reduced weight and fat mass and improved total and low-density lipoprotein cholesterol more than DR. IF prescribed in energy balance did notimprove health compared with other groups, despite modest weight loss.

Item Type: Article
Authors/Creators:Hutchison, AT and Liu, B and Wood, RE and Vincent, AD and Thompson, CH and O'Callaghan, NJ and Wittert, GA and Heilbronn, LK
Journal or Publication Title: Obesity
Publisher: John Wiley & Sons
ISSN: 1930-7381
DOI / ID Number:
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© 2018 The Obesity Society

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