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Abstract

Background and objective: Early menarche is increasing in prevalence worldwide, prompting clinical andpublic health interest on its links with pulmonary function. We aimed to investigate the relationship betweenearly menarche and lung function in middle age.Methods: The population-based Tasmanian LongitudinalHealth Study (born 1961; n = 8583), was initiated in 1968.The 5th Decade follow-up data (mean age: 45 years)included age at menarche and complex lung function testing. The 6th Decade follow-up (age: 53 years) repeated spirometry and gas transfer factor. Multiple linear regressionand mediation analyses were performed to determine theassociation between age at menarche and adult lung function and investigate biological pathways, including the proportion mediated by adult-attained height.Results: Girls reporting an early menarche (Conclusion:Early menarche was associated withreduced adult lung function. This is the first study toinvestigate post-BD outcomes and quantify the partialrole of adult height in this association.

Item Type:	Article
Authors/Creators:	Campbell, B and Simpson, JA and Bui, DS and Lodge, CJ and Lowe, AJ and Matheson, MC and Bowatte, G and Burgess, JA and Hamilton, GS and Leynaert, B and Gomez Real, F and Thomas, PS and Giles, GG and Frith, PA and Johns, DP and Mishra, G and Garcia-Aymerich, J and Jarvis, D and Abramson, MJ and Walters, EH and Perret, JL and Dharmage, SC
Keywords:	menarche, lung function, population health, cohort studies, epidemiology, longitudinal studies, pulmonary function tests
Journal or Publication Title:	Respirology
Publisher:	Blackwell Science
ISSN:	1323-7799
DOI / ID Number:	https://doi.org/10.1111/resp.13643
Copyright Information:	© 2019 Asian Pacific Society of Respirology
Related URLs:	UTAS Profile: Walters, EH
Item Statistics:	View statistics for this item

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