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Assessing urinary levels of IL-18, NGAL and albumin creatinine ratio in patients with diabetic nephropathy

Sueud, T, Hadi, NR, Abdulameer, R, Jamil, DA and Al-Aubaidy, HA ORCID: 0000-0001-9564-0120 2019 , 'Assessing urinary levels of IL-18, NGAL and albumin creatinine ratio in patients with diabetic nephropathy' , Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 13, no. 1 , pp. 564-568 , doi: 10.1016/j.dsx.2018.11.022.

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Abstract

Aims: Diabetic nephropathy (DN) is a serious microvascular complication of a longstanding hyperglycemia. This study aims to evaluate whether urinary neutrophil gelatinase-associated lipocalin (NGAL)and urinary Interleukin-18 possess a better diagnostic value than albumin creatinine ratio in assessingthe severity of nephropathy in patients with type 2 diabetes mellitus (T2DM).Material & methods: Ninety participants diagnosed with T2DM were recruited and they were dividedinto three study groups according to their albumin/creatinine ratio (ACR): (Normoalbuminuria group,Microalbuminuria group, and Macroalbuminuria group). A matching of Ninety healthy subjects wereincluded as controls. Blood and urine samples were collected to measure various markers of glycemiccontrol and kidney function.Results: IL-18 levels were not changed significantly between all study groups (P > 0.05), despite a significant positive correlation between IL-18 and urinary albumin levels.NGAL levels were significantly increased in Microalbuminuria group and Macroalbuminuria group ascompared to the control and Normoalbuminuria groups. NGAL was also positively correlated with urinary albumin and ACR, but negatively correlated with the age and body mass index. Receiver OperatingCharacteristic curves revealed that for early detection of DN, the best cutoff values to discriminate DNand diabetic without nephropathy groups were ˃ 21.4 ng/ml for NGAL (94.67 sensitivity, 26.67% specificity), ≤0.34 pg/mL for IL-18 (72% sensitivity, 53.33% specificity), and ˃29.8 mg/g for ACR (80% sensitivity,100% specificity).Conclusion: We conclude that the urinary ACR is a more accurate individual biomarker of DN whencompared to both NGAL and IL-18.

Item Type: Article
Authors/Creators:Sueud, T and Hadi, NR and Abdulameer, R and Jamil, DA and Al-Aubaidy, HA
Keywords: albumin creatinine ration, diabetic nephropathy, Interlukin-18; neutrophil gelatinase-associated lipocalin; Type 2 diabetes
Journal or Publication Title: Diabetes and Metabolic Syndrome: Clinical Research and Reviews
Publisher: Elsevier Ltd.
ISSN: 1871-4021
DOI / ID Number: 10.1016/j.dsx.2018.11.022
Copyright Information:

© 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.

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