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Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation

Wang, D, Chai, X-q, Magnussen, CG ORCID: 0000-0002-6238-5730, Zosky, GR ORCID: 0000-0001-9039-0302, Shu, S-h, Wei, X and Hu, S-s 2019 , 'Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation' , Pulmonary Pharmacology and Therapeutics, vol. 58 , pp. 1-6 , doi: 10.1016/j.pupt.2019.101833.

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While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.

Item Type: Article
Authors/Creators:Wang, D and Chai, X-q and Magnussen, CG and Zosky, GR and Shu, S-h and Wei, X and Hu, S-s
Keywords: Acute respiratory distress syndrome (ARDS), Mechanical ventilation, Renin-angiotensin system (RAS), ventilator-induced lung injury (VILI)
Journal or Publication Title: Pulmonary Pharmacology and Therapeutics
Publisher: Academic Press Ltd Elsevier Science Ltd
ISSN: 1094-5539
DOI / ID Number: 10.1016/j.pupt.2019.101833
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© 2019 Elsevier Ltd. All rights reserved.

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