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Differentiation of cognitive deficit profiles in Multiple Sclerosis patients: Latent profile analysis


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Slavkovic, S, Lazic, M, Honan, C ORCID: 0000-0001-5735-4270, Nad, C, Brkic-Jovanovic, N and Golubovic, S 2019 , 'Differentiation of cognitive deficit profiles in Multiple Sclerosis patients: Latent profile analysis' , Medical Principles and Practice, vol. 28, no. 4 , pp. 373-379 , doi: 10.1159/000499312.

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Objective: The purpose of this study was to ascertain whether the application of the Audio Recorded Cognitive Screen(ARCS) in cognitive functioning screening of persons withmultiple sclerosis (MS) differentiates profiles of existing cognitive deficits (CDs) and whether this instrument can discriminate accurately between subjects who are cognitivelyintact (CI) and those with a cognitive disorder. Subjects and Methods: The research was conducted on a sample of 359subjects, with two subsets of participants: 108 persons witha relapsing-remitting form of MS and 251 persons from thegeneral population. Results: We labeled the three profilesobtained by applying the ARCS questionnaire: the CI profile,the profile of CI with visuospatial difficulties, and the profileof persons with CD. Conclusion: ARCS has the ability to differentiate persons with a CD from those without, both in asample of persons suffering from MS and in a sample of persons from the general population. This finding indicates thatthis instrument is well suited for profiling the cognitive status into specific categories, which puts it among the instruments with a wide range of implementation.

Item Type: Article
Authors/Creators:Slavkovic, S and Lazic, M and Honan, C and Nad, C and Brkic-Jovanovic, N and Golubovic, S
Keywords: multiple sclerosis, latent profile, work, cognitive ability, diagnostic, Multiple Sclerosis, prognosis
Journal or Publication Title: Medical Principles and Practice
Publisher: Karger
ISSN: 1011-7571
DOI / ID Number: 10.1159/000499312
Copyright Information:

© 2019 The Author(s) Published by S. Karger AG, Basel. This is an Open Access article licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (, applicable to the online version of the article only. Usage and distribution for commercial purposes requires written permission.

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