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Pre-quit nicotine decreases nicotine self-administration and attenuates cue- and drug-induced reinstatement

Clemens, KJ, Stuart, A and Ferguson, SG ORCID: 0000-0001-7378-3497 2019 , 'Pre-quit nicotine decreases nicotine self-administration and attenuates cue- and drug-induced reinstatement' , Journal of Psychopharmacology, vol. 33, no. 3 , pp. 364-371 , doi:

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Background: Administration of smoking cessation medications in anticipation of a nominated quit date can promote abstinence. How this occurs isnot widely understood, but may be due to the disruption of contingencies between smoking behaviour and acute drug effects.Aims: The aim of this study was to explore this relationship, we examined the effect of pre-quit nicotine replacement therapy on susceptibility torelapse in an animal model of nicotine dependence.Methods: Rats were trained to intravenously self-administer nicotine across 20 days. Continuous low-dose nicotine was administered via a miniosmotic pump either across the last 7 days of self-administration and across 6 days of extinction, or across extinction only. Cue- and drug-inducedreinstatements of responding were then measured with mini-pumps retained, the day after mini-pump removal or one week later.Results: Pre-quit nicotine administration markedly reduced self-administration across the last days of training as the response, and its associatedcues, no longer reliably predicted an acute drug effect. Pre-quit, but not post-quit, nicotine administration significantly attenuated cue-inducedreinstatement once mini-pumps were removed, indicating that the contingency disruption across training reduced the conditioned reinforcingproperties of the cue at test. Both pre-quit and post-quit nicotine attenuated nicotine-primed reinstatement.Conclusions: Together these results suggest that administration of a nicotine replacement prior to a nominated quit date may enhance resistance torelapse via disruption of the contingency between a response, its associated cues, and a rewarding nicotine effect.

Item Type: Article
Authors/Creators:Clemens, KJ and Stuart, A and Ferguson, SG
Keywords: pre-quit nicotine, self-administration, rat, nicotine replacement therapy, smoking cessation
Journal or Publication Title: Journal of Psychopharmacology
Publisher: SAGE Publications
ISSN: 0269-8811
DOI / ID Number:
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Copyright 2019 The Authors

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