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Pre-quit nicotine decreases nicotine self-administration and attenuates cue- and drug-induced reinstatement
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ORCID: 0000-0001-7378-3497 2019
, 'Pre-quit nicotine decreases nicotine self-administration and attenuates cue- and drug-induced reinstatement'
, Journal of Psychopharmacology, vol. 33, no. 3
, pp. 364-371
, doi: https://doi.org/10.1177/0269881118822074.
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Abstract
Background: Administration of smoking cessation medications in anticipation of a nominated quit date can promote abstinence. How this occurs isnot widely understood, but may be due to the disruption of contingencies between smoking behaviour and acute drug effects.Aims: The aim of this study was to explore this relationship, we examined the effect of pre-quit nicotine replacement therapy on susceptibility torelapse in an animal model of nicotine dependence.Methods: Rats were trained to intravenously self-administer nicotine across 20 days. Continuous low-dose nicotine was administered via a miniosmotic pump either across the last 7 days of self-administration and across 6 days of extinction, or across extinction only. Cue- and drug-inducedreinstatements of responding were then measured with mini-pumps retained, the day after mini-pump removal or one week later.Results: Pre-quit nicotine administration markedly reduced self-administration across the last days of training as the response, and its associatedcues, no longer reliably predicted an acute drug effect. Pre-quit, but not post-quit, nicotine administration significantly attenuated cue-inducedreinstatement once mini-pumps were removed, indicating that the contingency disruption across training reduced the conditioned reinforcingproperties of the cue at test. Both pre-quit and post-quit nicotine attenuated nicotine-primed reinstatement.Conclusions: Together these results suggest that administration of a nicotine replacement prior to a nominated quit date may enhance resistance torelapse via disruption of the contingency between a response, its associated cues, and a rewarding nicotine effect.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Clemens, KJ and Stuart, A and Ferguson, SG |
| Keywords: | pre-quit nicotine, self-administration, rat, nicotine replacement therapy, smoking cessation |
| Journal or Publication Title: | Journal of Psychopharmacology |
| Publisher: | SAGE Publications |
| ISSN: | 0269-8811 |
| DOI / ID Number: | https://doi.org/10.1177/0269881118822074 |
| Copyright Information: | Copyright 2019 The Authors |
| Related URLs: | |
| Item Statistics: | View statistics for this item |
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