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Plasma lipoprotein-associated phospholipase A2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment

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Zhu, S, Wei, X, Yang, X, Huang, Z, Chang, Z, Xie, F, Yang, Q, Ding, C ORCID: 0000-0002-9479-730X, Xiang, W, Yang, H, Xia, Y, Feng, Z-P, Sun, H-S, Yenari, MA, Shi, L, Mok, VCT and Wang, Qing 2019 , 'Plasma lipoprotein-associated phospholipase A2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment' , Aging and Disease, vol. 10, no. 4 , pp. 834-846 , doi: 10.14336/AD.2019.0304.

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Abstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2) and superoxide dismutase (SOD) are linked to regulating vascular/neuro-inflammation and stroke. Using a retrospective design, we investigated whether circulating Lp-PLA2 and SOD in cerebral small vessel disease (CSVD) patients were associated with cognitive impairment. Eighty-seven CSVD patients were recruited. Plasma Lp-PLA2 and SOD were determined, and cognitive status was measured by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The severity of white matter hypoerintensities (WMHs) in CSVD patients was rated according to Fazekas scales, and Lp-PLA2/SOD levels and MMSE/MoCA were compared. Multiple linear regressions were used to evaluate the relationship between Lp-PLA2 and SOD and the cognitive impairment. Ordinal logistic regression and generalized linear models (OLRGLMs) were applied to confirm whether Lp-PLA2 and SOD are independent risk factors for cognitive impairment in CVSD. Lp-PLA2 and SOD with mild or severe cognitive impairment were lower than those with normal congnition. Lp-PLA2 and SOD in CSVD patients with severe WMHs were significantly lower than those with mild or moderate WMH lesions. We noted positive linear associations of Lp-PLA and SOD with cognitive impairment in CSVD, independent of LDL-C. OLRGLMs confirmed that Lp-PLA2 and SOD were independent risk factors of cognitive impairment in CSVD. Lp-PLA2 and SOD are independently associated with cognitive impairment and WMH lesion, and may be useful for the rapid evaluation of cognitive impairment in CSVD. Lp-PLA2/SOD are modifiable factors that may be considered as therapeutic targets for preventing cognitive impairment in CSVD.

Item Type: Article
Authors/Creators:Zhu, S and Wei, X and Yang, X and Huang, Z and Chang, Z and Xie, F and Yang, Q and Ding, C and Xiang, W and Yang, H and Xia, Y and Feng, Z-P and Sun, H-S and Yenari, MA and Shi, L and Mok, VCT and Wang, Qing
Keywords: Lp-PLA2, cerebral small vessel disease, cognition, superoxide dismutase
Journal or Publication Title: Aging and Disease
Publisher: Buck Institute for Age Research
ISSN: 2152-5250
DOI / ID Number: 10.14336/AD.2019.0304
Copyright Information:

Copyright: © 2019 Zhu S et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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