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Dietary patterns and β-amyloid deposition in aging Australian women

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Hill, E ORCID: 0000-0002-7587-9051, Clifton, P, Goodwill, AM, Dennerstein, L, Campbell, S and Szoeke, C 2018 , 'Dietary patterns and β-amyloid deposition in aging Australian women' , Alzheimer's & Dementia, vol. 4 , pp. 535-541 , doi: 10.1016/j.trci.2018.09.007.

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Abstract

Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid-β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women.Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning.Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.

Item Type: Article
Authors/Creators:Hill, E and Clifton, P and Goodwill, AM and Dennerstein, L and Campbell, S and Szoeke, C
Keywords: Alzheimer's disease, biomarkers, diet, dietary pattern, factor analysis, neuropathology, nutrition, women, β-amyloid protein
Journal or Publication Title: Alzheimer's & Dementia
Publisher: Elsevier Inc.
ISSN: 1552-5260
DOI / ID Number: 10.1016/j.trci.2018.09.007
Copyright Information:

Copyright 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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