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Abstract

Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid-β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women.Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning.Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.

Item Type:	Article
Authors/Creators:	Hill, E and Clifton, P and Goodwill, AM and Dennerstein, L and Campbell, S and Szoeke, C
Keywords:	Alzheimer's disease, biomarkers, diet, dietary pattern, factor analysis, neuropathology, nutrition, women, β-amyloid protein
Journal or Publication Title:	Alzheimer's & Dementia
Publisher:	Elsevier Inc.
ISSN:	1552-5260
DOI / ID Number:	https://doi.org/10.1016/j.trci.2018.09.007
Copyright Information:	Copyright 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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