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Telomere length and lung function in a population-based cohort of children and mid-life adults

Nguyen, MT, Saffery, R, Burgner, D, Lycett, K, Vryer, R, Grobler, A, Dwyer, T, Ranganathan, S and Wake, M 2019 , 'Telomere length and lung function in a population-based cohort of children and mid-life adults' , Pediatric Pulmonology , pp. 1-9 , doi: 10.1002/ppul.24489.

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Objective: Telomere length is associated with poorer lung health in older adults, possibly from cumulative risk factor exposure, but data are lacking in pediatric and population-based cohorts. We examined associations of telomere length with lung function in children and mid-life adults.Methods: Data were drawn from a population-based cross-sectional study of 11 to 12 year-olds and mid-life adults. Lung function was assessed by spirometric FEV1, FVC, FEV1 /FVC ratio, and MMEF25-75. Telomere length was measured by quantitative polymerase chain reaction from blood and expressed as the amount of telomeric genomic DNA to the beta-globin gene (T/S ratio). Associations of telomere length with spirometric parameters were tested by linear and logistic regression models, adjusting for potential confounders of sex, age, body mass index, socioeconomic position, physical activity, inflammation, asthma, pubertal status, and smoking.Results: Mean T/S ratio was 1.09 (n = 1206; SD 0.55) in children and 0.81 (n = 1343; SD 0.38) in adults. In adults, for every additional unit in T/S ratio, FEV1/FVC and MMEF25-75 z-scores were higher (β 0.21 [95% confidence interval, CI; 0.06-0.36] and 0.23 [95% CI; 0.08-0.38], respectively), and the likelihood of being in the lowest quartile for FEV1/FVC and MMEF25-75 z-scores was lower (odds ratios 0.59 [95% CI, 0.39-0.89] and 0.64 [95% CI, 0.41-0.99], respectively). No evidence of association was seen for adult FEV1 or FVC, or any childhood spirometric index after adjustments.Conclusion:Shorter telomere length showed moderate associations with poorer airflow parameters, but not vital capacity (lung volume) in mid-life adults. However, there was no convincing evidence of associations in children.

Item Type: Article
Authors/Creators:Nguyen, MT and Saffery, R and Burgner, D and Lycett, K and Vryer, R and Grobler, A and Dwyer, T and Ranganathan, S and Wake, M
Keywords: aging, cell senescence, life course, national cohort, spirometry
Journal or Publication Title: Pediatric Pulmonology
Publisher: Wiley-Liss
ISSN: 8755-6863
DOI / ID Number: 10.1002/ppul.24489
Copyright Information:

Copyright 2019 Wiley Periodicals, Inc.

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