Preview

PDF (Article In Press) 134887 - Incide...pdf | Download (3MB) | Preview

Abstract

Background: Long-termcancer, cardiovascular disease, diabetes and osteoarthritismay increase the risk ofmentaldisorders, but which was more harmful and whether the associations differed between genders is unclear.Methods: We included 115,094 participants (54.3% women) aged 45–64 years from the 45 and Up Study whowere free of depression, anxiety, and Parkinson's disease at baseline (2006–2009). The incidence of depressionand anxiety was identified using claim databases during follow-up until December 2016. Cox regression modelswere used to examine the association of cancer, cardiovascular disease, diabetes, and osteoarthritis at baselinewith incident depression and anxiety.Findings: During a mean eight-year follow-up (958,785 person-year), the cumulative incidence of depression andanxiety was 12.5% and 5.9% in the healthy population. Hazard ratios ([HRs] (95% CI) versus healthy population)for incident depression associated with long-term cancer, cardiovascular disease, diabetes, and osteoarthritiswere 1.19 (95% CI: 1.13–1.25), 1.08 (1.00–1.16)), 1.18 (1.09–1.28), and 1.94 (1.80–2.10), respectively. The correspondingHRs (95% CIs) for incident anxiety were 1.11 (1.03–1.20), 1.26 (1.14–1.39), 1.10 (0.98–1.24), and 2.01(1.80–2.23), respectively. The positive association between cancer and incident depression was more evident inmen (HR (95% CI): 1.24 (1.13–1.35) than in women (1.14 (1.07–1.21). Long-term diabetes was an independentrisk factor for incident anxiety in men (1.21 (1.02–1.44) but not in women (1.09 (0.93–1.28)).Interpretation: Long-term osteoarthritis, cardiovascular disease, and cancer were independent risk factors for incidentdepression and anxiety in both genders with osteoarthritis having the highest relative risk.

Item Type:	Article
Authors/Creators:	Shang, X and Peng, W and Hill, E and Szoeke, C and He, M and Zhang, L
Keywords:	cardiovascular disease, cancer, diabetes, osteoarthritis, depression, anxiety
Journal or Publication Title:	EClinicalMedicine
Publisher:	Elsevier Ltd
ISSN:	2589-5370
DOI / ID Number:	https://doi.org/10.1016/j.eclinm.2019.08.010
Copyright Information:	Copyright 2019 Published by Elsevier Ltd. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Item Statistics:	View statistics for this item

Actions (login required)

Item Control Page