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Abstract

Alzheimer's disease (AD) risk increases with age and lacks efficacious pharmacological options. Summaries of the existing evidence reveal an association between Mediterranean-style diet adherence and reduced AD incidence; however, no review has investigated this relationship with respect to the hallmark AD biomarkers (tau and beta-amyloid) that manifest decades before clinical symptomatology. MEDLINE, PubMed, PsycINFO, Google Scholar, and SCOPUS databases were systematically searched to identify peer-reviewed articles investigating diet and AD biomarkers in the last 2 decades. Two thousand seven hundred twenty-six records were extracted, quality assessed, and double-blind screened by 2 authors. Fifteen studies met the inclusion criteria and 13 studies found a significant relationship. Of these, 4 studies found a high-glycemic load was related to an increase in AD biomarker burden; 6 found adherence to a Mediterranean or "AD-protective" dietary pattern conferred a reduction in AD biomarker burden. Meta-analysis revealed a small but significant effect of diet on AD biomarkers (β = 0.11 [95% CI 0.04-0.17], p = 0.002). This systematic review supports the notion that diet and nutrition display potential for nonpharmacological AD prevention.

Item Type:	Article
Authors/Creators:	Hill, E and Goodwill, AM and Gorelik, A and Szoeke, C
Keywords:	Alzheimer's disease, beta-amyloid, biomarkers, diet, nutrition, Tau
Journal or Publication Title:	Neurobiology of Aging
Publisher:	Elsevier Science Inc
ISSN:	0197-4580
DOI / ID Number:	https://doi.org/10.1016/j.neurobiolaging.2018.12.008
Copyright Information:	Copyright 2019 Elsevier Inc. All rights reserved.
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