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A new evolutionary algorithm-based home monitoring device for Parkinson's dyskinesia


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Lones, MA, Alty, JE, Cosgrove, J, Duggan-Carter, P, Jamieson, S, Naylor, RF, Turner, AJ and Smith, SL 2017 , 'A new evolutionary algorithm-based home monitoring device for Parkinson's dyskinesia' , Journal of Medical Systems, vol. 41, no. 176 , pp. 1-8 , doi: 10.1007/s10916-017-0811-7.

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Parkinson’s disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent. To minimise dyskinesia, it is necessary to accurately titrate the amount of medication given and monitor a patient’s movements. In this paper, we describe a new home monitoring device that allows dyskinesia to be measured as a patient goes about their daily activities, providing information that can assist clinicians when making changes to medication regimens. The device uses a predictive model of dyskinesia that was trained by an evolutionary algorithm, and achieves AUC>0.9 when discriminating clinically significant dyskinesia.

Item Type: Article
Authors/Creators:Lones, MA and Alty, JE and Cosgrove, J and Duggan-Carter, P and Jamieson, S and Naylor, RF and Turner, AJ and Smith, SL
Keywords: neurology, neurodegenerative, evolutionary algorithms, Parkinson's
Journal or Publication Title: Journal of Medical Systems
Publisher: Springer Nature Switzerland
ISSN: 0148-5598
DOI / ID Number: 10.1007/s10916-017-0811-7
Copyright Information:

Copyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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