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Piloting a clinical laboratory method to evaluate the influence of potential modified risk tobacco products on smokers' quit-related motivation, choice, and behavior

Ozga-Hess, JE, Felicione, NJ, Ferguson, SG ORCID: 0000-0001-7378-3497, Dino, G, Elswick, D, Whitworth, C, Turiano, N and Blank, MD 2019 , 'Piloting a clinical laboratory method to evaluate the influence of potential modified risk tobacco products on smokers' quit-related motivation, choice, and behavior' , Addictive Behaviors, vol. 99 , pp. 1-9 , doi: 10.1016/j.addbeh.2019.106105.

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Abstract

Research methods are needed that can predict whether the availability of potential modified risk tobacco products (MRTPs) may influence smokers' quit-related motivation, choice, and behavior. This pilot study assessedthe primary outcomes of feasibility and adherence to address this need using an electronic cigarette (ECIG) as amodel MRTP. Cigarette smokers were randomly assigned to use only their own brand of cigarettes (OB-only) or asecond-generation ECIG (18 ng/ml nicotine) plus their OB cigarettes (ECIG+OB) ad libitum for four weeks.Participants logged products using a mobile device, collected used cigarette filters, and provided saliva samplesevery day for analysis of cotinine. They returned to the lab once per week to provide a breath sample and acceptor decline a choice to quit all tobacco products (i.e., cigarettes and/or ECIGs). They also returned for a onemonth follow-up visit. Of those participants randomized (n = 60), 56.7% completed the 4-week intervention and40.0% completed the follow-up visit. The primary reason for withdrawal was poor adherence with mobile deviceuse. Comparable numbers of participants in each group chose to make a quit attempt, although more OB-onlyparticipants chose to quit during the first two weeks and more ECIG+OB participants during the last two weeks.With protocol modifications to reduce participation burden, the current method might ultimately be used byregulators to predict how smokers' quit-related motivation, choice, and behavior are influenced by current andfuture MRTPs.

Item Type: Article
Authors/Creators:Ozga-Hess, JE and Felicione, NJ and Ferguson, SG and Dino, G and Elswick, D and Whitworth, C and Turiano, N and Blank, MD
Keywords: smoking cessation, e-cigs, electronic cigarettes
Journal or Publication Title: Addictive Behaviors
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0306-4603
DOI / ID Number: 10.1016/j.addbeh.2019.106105
Copyright Information:

© 2019 Published by Elsevier Ltd.

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