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High pyridine generation in ceftazidime-icodextrin admixtures used to treat peritoneal dialysis-associated peritonitis

Kaur, H, Harmanjeet, H, Wanandy, T ORCID: 0000-0003-4703-0488, Castelino, RL, Sud, K, Jose, MD ORCID: 0000-0002-9589-0071, Peterson, GM ORCID: 0000-0002-6764-3882 and Patel, RP ORCID: 0000-0001-9344-1013 2019 , 'High pyridine generation in ceftazidime-icodextrin admixtures used to treat peritoneal dialysis-associated peritonitis' , Clinical Therapeutics , pp. 1-6 , doi: 10.1016/j.clinthera.2019.08.021.

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Abstract

Purpose: To investigate the amount of pyridinegenerated from degradation of ceftazidime inicodextrin peritoneal dialysis (PD) solutions.Methods: PD solutions that contained 1 and 1.5 gof ceftazidime were stored at 25 °C for 12 hours andthen at 37 °C for 14 hours. An aliquot waswithdrawn at predefined time points and analyzedfor the concentrations of ceftazidime and pyridine.Findings: The amount of pyridine generated was>225% and 400% of its maximum recommendeddaily exposure in the 1- and 1.5-g ceftazidime-PDadmixtures, respectively.Implications: Until these results are confirmed withappropriate in vivo studies, intermittent intraperitonealdosing of ceftazidime admixed with icodextrin shouldbe used with caution and appropriate clinicalmonitoring or a suitable alternative antibiotic shouldbe used.

Item Type: Article
Authors/Creators:Kaur, H and Harmanjeet, H and Wanandy, T and Castelino, RL and Sud, K and Jose, MD and Peterson, GM and Patel, RP
Keywords: ceftazidime, peritoneal dialysis, peritonitis, pyridine, stability, toxicity
Journal or Publication Title: Clinical Therapeutics
Publisher: Excerpta Medica Inc
ISSN: 0149-2918
DOI / ID Number: 10.1016/j.clinthera.2019.08.021
Copyright Information:

Copyright 2019 Elsevier Inc.

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