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Reduced cortical somatostatin gene expression in a rat model of maternal immune activation

Duchatel, RJ, Harms, LR, Meehan, CL ORCID: 0000-0002-2408-5112, Michie, PT, Bigland, MJ, Smith, DW, Jobling, P, Hodgson, DM and Tooney, PA 2019 , 'Reduced cortical somatostatin gene expression in a rat model of maternal immune activation' , Psychiatry Research, vol. 282 , pp. 1-9 , doi: 10.1016/j.psychres.2019.112621.

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Abstract

Alterations in GABAergic interneurons and glutamic acid decarboxylase (GAD) are observed in the brains ofpeople with schizophrenia. Studies also show increased density of interstitial white matter neurons (IWMN),including those containing GAD and somatostatin (SST) in the brain in schizophrenia. Maternal immune activation can be modelled in rodents to investigate the relationship between prenatal exposure to infections andincreased risk of developing schizophrenia. We reported that maternal immune activation induced an increase indensity of somatostatin-positive IWMN in the adult rat offspring. Here we hypothesised that maternal immuneactivation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expressionas well as increase the density of GAD-positive IWMNs in the adult offspring. SST gene expression was significantly reduced in the cingulate cortex of adult offspring exposed to late gestation maternal immune activation. There was no change in cortical GAD gene expression nor GAD-positive IWMN density in adults ratsexposed to maternal immune activation at either early or late gestation. This suggests that our model of maternalimmune activation induced by prenatal exposure of rats to polyinosinic:polycytidylic acid during late gestation isable to recapitulate changes in SST but not other GABAergic neuropathologies observed in schizophrenia.

Item Type: Article
Authors/Creators:Duchatel, RJ and Harms, LR and Meehan, CL and Michie, PT and Bigland, MJ and Smith, DW and Jobling, P and Hodgson, DM and Tooney, PA
Keywords: somatostatin, schizophrenia, maternal immune activation, cingulate cortex, white matter neuron
Journal or Publication Title: Psychiatry Research
Publisher: Elsevier Sci Ireland Ltd
ISSN: 0165-1781
DOI / ID Number: 10.1016/j.psychres.2019.112621
Copyright Information:

Crown Copyright © 2019 Published by Elsevier B.V. All rights reserved.

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