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Redefining the Multiple Sclerosis Severity Score (MSSS): the effect of sex and onset phenotype

Zhou, Y ORCID: 0000-0003-1962-2574, Claflin, SB ORCID: 0000-0001-6545-946X, Stankovich, J, van der Mei, I ORCID: 0000-0001-9009-7472, Simpson Jr, S ORCID: 0000-0001-6521-3056, Roxburgh, RH, Kalincik, T, Blizzard, L ORCID: 0000-0002-9541-6943, Lugaresi, A, Alroughani, R, Sajedi, SA, Butzkueven, H, Pucci, E, Spitaleri, D, Granella, F, Cristiano, E, Yamout, B, Hughes, S, Gouider, R, Sanchez Menoyo, JL, Olascoaga, J, McGuigan, C, Shaw, C, Kermode, AG, Kasa, K, Al-Harbi, T, Altintas, A, Laureys, G, Fragoso, Y, Hardy, TA, Csepany, T, Sirbu, CA, Decoo, D, Sas, A, Alvarez-Cermeno, JC, Kotkata, K, Millan-Pascual, J and Taylor, BV 2019 , 'Redefining the Multiple Sclerosis Severity Score (MSSS): the effect of sex and onset phenotype' , Multiple Sclerosis Journal, no. Octobe , pp. 1-10 , doi: 10.1177/1352458519881994.

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Abstract

Background: The Multiple Sclerosis Severity Score (MSSS) is a widely used measure of the disability progression rate. However, the global MSSS may not be the best basis for comparison between all patient groups.Objective: We evaluated sex-specific and onset phenotype-specific MSSS matrices to determine if they were more effective than the global MSSS as a basis for comparison within these subsets.Methods: Using a large international dataset of multiple sclerosis (MS) patient records and the original MSSS algorithm, we constructed global, sex-specific and onset phenotype-specific MSSS matrices. We compared matrices using permutation analysis.Results: Our final dataset included 30,203 MS cases, with 28.9% males and 6.5% progressive-onset cases. Our global MSSS matrix did not differ from previously published data (p > 0.05). The progressive-onset-specific matrix differed significantly from the relapsing-onset-specific matrix (p Conclusion: The differences in the disability accrual rate between progressive- and relapsing-onset MS have a significant effect on MSSS. An onset-specific MSSS should be used when comparing the rate of disability progression among progressive-onset cases and for mixed cohorts.

Item Type: Article
Authors/Creators:Zhou, Y and Claflin, SB and Stankovich, J and van der Mei, I and Simpson Jr, S and Roxburgh, RH and Kalincik, T and Blizzard, L and Lugaresi, A and Alroughani, R and Sajedi, SA and Butzkueven, H and Pucci, E and Spitaleri, D and Granella, F and Cristiano, E and Yamout, B and Hughes, S and Gouider, R and Sanchez Menoyo, JL and Olascoaga, J and McGuigan, C and Shaw, C and Kermode, AG and Kasa, K and Al-Harbi, T and Altintas, A and Laureys, G and Fragoso, Y and Hardy, TA and Csepany, T and Sirbu, CA and Decoo, D and Sas, A and Alvarez-Cermeno, JC and Kotkata, K and Millan-Pascual, J and Taylor, BV
Keywords: multiple sclerosis, Multiple Sclerosis Severity Score, disability progression, onset phenotype
Journal or Publication Title: Multiple Sclerosis Journal
Publisher: Arnold
ISSN: 1352-4585
DOI / ID Number: 10.1177/1352458519881994
Copyright Information:

Copyright 2019 The Authors

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