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Chelation Therapy for Methylmercury(II) Poisoning. Synthesis and Determination of Solubility Properties of MeHg(II) Complexes of Thiol and Dithiol Antidotes
journal contribution
posted on 2023-05-25, 22:33 authored by Arnold, AP, Canty, AJ, Moors, PWMethylmercury complexes of the most widely studied antidotes for mercury poisoning have been prepared, and both the water solubility and l-octanol/water partition coefficients determined for these complexes and the L-cysteine complex. New complexes of N-acetyl-D,L-penicillamine, 2-mercaptosuccinic acid, meso-dimercaptosuccinic acid, and Unithiol have been synthesized and characterized, and are found to have the formulations MeHgSCMe2CH(NHCOMe)CO2H, MeHgSCH(CO2H)CH2CO2H, MeHgSCH(CO2H)CH(CO2H)SHgMe, and Na[MeHgSCH2CH(SHgMe)CH2SO3)], respectively. Trends in octanol/water partition coefficients are consistent with reported studies of the effectiveness of antidotes for methylmercury poisoning and redistribution of methylmercury) on administration of antidotes, particularly for British anti-Lewisite, Unithiol, and meso-dimercaptosuccinic acid.
History
Publication title
Journal of Inorganic BiochemistryVolume
19Article number
4Number
4Pagination
319-327Publication status
- Published
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The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted
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