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Abstract

Rationale: Interactions between early life and adult insults on lungfunction decline are not well understood, with most studiesinvestigating prebronchodilator (pre-BD) FEV1 decline.Objectives: To investigate relationships between adult risk factorsand pre- and post-BD lung function decline and their potential effectmodification by early life and genetic factors.Methods: Multiple regression was used to examine associationsbetween adult exposures (asthma, smoking, occupational exposures,traffic pollution, and obesity) and decline in both pre- and post-BDspirometry (forced expiratory volume in 1 s [FEV1], forced vitalcapacity [FVC], and FEV1/FVC) between ages 45 and 53 years in theTasmanian Longitudinal Health Study (n = 857). Effect modificationof these relationships by childhood respiratory risk factors,including low childhood lung function and GST (glutathioneS-transferase) gene polymorphisms, was investigated.Results: Baseline asthma, smoking, occupational exposure tovapors/gases/dusts/fumes, and living close to traffic were associatedwith accelerated decline in both pre- and post-BD FEV1. Thesefactors were also associated with FEV1/FVC decline. Occupationalexposure to aromatic solvents was associated with pre-BD but notpost-BD FEV1 decline. Maternal smoking accentuated the effect ofpersonal smoking on pre- and post-BD FEV1 decline. Lowerchildhood lung function and having the GSTM1 null alleleaccentuated the effect of occupational exposure to vapors/gases/dusts/fumes and personal smoking on post-BD FEV1 decline.Incident obesity was associated with accelerated decline in FEV1 andmore pronounced in FVC.Conclusions: This study provides new evidence for accentuationof individual susceptibility to adult risk factors by low childhoodlung function, GSTM1 genotype, and maternal smoking.

Item Type:	Article
Authors/Creators:	Bui, DS and Perret, JL and Walters, EH and Abramson, MJ and Burgess, JA and Bui, MQ and Bowatte, G and Lowe, AJ and Russell, MA and Alif, SM and Thompson, BR and Hamilton, GS and Giles, GG and Thomas, PS and Morrison, S and Johns, DP and Knibbs, LD and Zock, JP and Marcon, A and Garcia-Aymerich, J and Erbas, B and Jarvis, D and Svanes, C and Lodge, CJ and Dharmage, SC
Keywords:	lung function, decline, interaction, bronchodilator, susceptibility
Journal or Publication Title:	Annals of the American Thoracic Society
Publisher:	American Thoracic Society
ISSN:	2325-6621
DOI / ID Number:	10.1513/AnnalsATS.201904-329OC
Copyright Information:	Copyright 2020 by the American Thoracic Society
Related URLs:	UTAS Profile: Walters, EH
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