Open Access Repository

Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish

Lidgerwood, GE, Hewitt, AW ORCID: 0000-0002-5123-5999 and Pebay, A 2019 , 'Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish' , Current Opinion in Pharmacology, vol. 48 , pp. 114-119 , doi: 10.1016/j.coph.2019.09.003.

Full text not available from this repository.

Abstract

Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation and modelling have relied on two-dimensional monocultures of specific cell types, which are not representative of the complexity of the human retina and optic nerve. Hence, more complex models of the human retina and optic nerve are required. Three-dimensional organoids and emerging cell culture methods may provide more physiologically relevant models to study developmental biology and pathology of the retina and optic nerve.

Item Type: Article
Authors/Creators:Lidgerwood, GE and Hewitt, AW and Pebay, A
Journal or Publication Title: Current Opinion in Pharmacology
Publisher: Elsevier Sci Ltd
ISSN: 1471-4892
DOI / ID Number: 10.1016/j.coph.2019.09.003
Copyright Information:

Copyright 2019 Elsevier Ltd.

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP