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Childhood pneumonia, pleurisy and lung function: A cohort study from the first to sixth decade of life

Perret, JL, Lodge, CJ, Lowe, AJ, Johns, DP ORCID: 0000-0002-1575-6850, Thompson, BR, Bui, DS, Gurrin, LC, Matheson, MC, McDonald, CF, Wood-Baker, R, Svanes, C, Thomas, PS, Giles, GG, Chang, AB, Abramson, MJ, Walters, EH ORCID: 0000-0002-0993-4374 and Dharmage, SC 2020 , 'Childhood pneumonia, pleurisy and lung function: A cohort study from the first to sixth decade of life' , Thorax, vol. 75, no. 1 , pp. 28-37 , doi: 10.1136/thoraxjnl-2019-213389.

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Abstract

Introduction: Adult spirometry following communityacquired childhood pneumonia has variably beenreported as showing obstructive or non-obstructivedeficits. We analysed associations between doctordiagnosed childhood pneumonia/pleurisy and morecomprehensive lung function in a middle-aged generalpopulation cohort born in 1961.Methods: Data were from the prospective population-based Tasmanian Longitudinal Health Study cohort.Analysed lung function was from ages 7 years(prebronchodilator spirometry only, n=7097), 45 years(postbronchodilator spirometry, carbon monoxidetransfer factor and static lung volumes, n=1220) and 53years (postbronchodilator spirometry and transfer factor,n=2485). Parent-recalled histories of doctor-diagnosedchildhood pneumonia and/or pleurisy were recorded atage 7. Multivariable linear and logistic regression wereused.Results: At age 7, compared with no episodes,childhood pneumonia/pleurisy-ever was associated withreduced FEV1:FVC for only those with current asthma(beta-coefficient or change in z-score=−0.20 SD, 95%CI −0.38 to –0.02, p=0.028, p interaction=0.036).At age 45, for all participants, childhood pneumonia/pleurisy-ever was associated with a restrictive pattern:OR 3.02 (1.5 to 6.0), p=0.002 for spirometric restriction(FVC less than the lower limit of normal plus FEV1:FVCgreater than the lower limit of normal); total lungcapacity z-score −0.26 SD (95% CI −0.38 to –0.13),pDiscussion: For this community-based population,doctor-diagnosed childhood pneumonia and/or pleurisywere associated with obstructed lung function at age 7for children who had current asthma symptoms, but withevidence of ’smaller lungs’ when in middle age.

Item Type: Article
Authors/Creators:Perret, JL and Lodge, CJ and Lowe, AJ and Johns, DP and Thompson, BR and Bui, DS and Gurrin, LC and Matheson, MC and McDonald, CF and Wood-Baker, R and Svanes, C and Thomas, PS and Giles, GG and Chang, AB and Abramson, MJ and Walters, EH and Dharmage, SC
Keywords: lung function, pneumonia
Journal or Publication Title: Thorax
Publisher: British Medical Assn.
ISSN: 0040-6376
DOI / ID Number: 10.1136/thoraxjnl-2019-213389
Copyright Information:

Copyright 2020 The Authors

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