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Long-term burden of increased body mass index from childhood on adult dyslipidemia: the i3C Consortium study

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Yan, Y, Bazzano, LA, Juonala, M, Raitakari, OT, Viikari, JSA, Prineas, R, Dwyer, T, Sinaiko, A, Burns, TL, Daniels, SR, Woo, JG, Khoury, PR, Urbina, EM, Jacobs, DR Jr, Hu, T, Steinberger, J, Venn, A ORCID: 0000-0001-7090-1398 and Chen, W 2019 , 'Long-term burden of increased body mass index from childhood on adult dyslipidemia: the i3C Consortium study' , Journal of Clinical Medicine, vol. 8, no. 10 , pp. 1-11 , doi: 10.3390/jcm8101725.

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Abstract

Background: Data are limited regarding the association of cumulative burden and trajectory of body mass index (BMI) from early life with adult lipid disorders. Methods: The study cohort consisted of 5195 adults who had BMI repeatedly measured 4 to 21 times from childhood and had blood lipid measurements of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) and information on lipid-lowering medications in the last adult survey. The area under the curve (AUC) was calculated as a measure of long-term burden (total AUC) and trends (incremental AUC) of BMI. Results: Participants with dyslipidemia, high LDL-C, low HDL-C and high TG had consistently and significantly higher BMI levels from childhood to adulthood compared to those with normal lipid levels. After adjusting for age, race, sex, and cohort, increased risk of adult dyslipidemia was significantly associated with higher values of childhood BMI, adulthood BMI, total AUC and incremental AUC, with odds ratio (95% confidence interval) = 1.22 (1.15-1.29), 1.85 (1.74-1.97), 1.61 (1.52-1.71), and 1.59 (1.50-1.69), respectively, and p Conclusions: Adults with dyslipidemia versus normal lipid levels have consistently higher levels and distinct life-course trajectories of BMI, suggesting that the impact of excessive body weight on dyslipidemia originates in early life.

Item Type: Article
Authors/Creators:Yan, Y and Bazzano, LA and Juonala, M and Raitakari, OT and Viikari, JSA and Prineas, R and Dwyer, T and Sinaiko, A and Burns, TL and Daniels, SR and Woo, JG and Khoury, PR and Urbina, EM and Jacobs, DR Jr and Hu, T and Steinberger, J and Venn, A and Chen, W
Keywords: body mass index, dyslipidemia, longitudinal study, childhood
Journal or Publication Title: Journal of Clinical Medicine
Publisher: MDPIAG
ISSN: 2077-0383
DOI / ID Number: 10.3390/jcm8101725
Copyright Information:

Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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