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Abstract

Fucoidans are a class of fucose‐rich sulfated polysaccharides derived from brownmacroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiasedassessment of pathways and processes affected by fucoidan, a placebo‐controlled double‐blind pilotstudy was performed in healthy volunteers. Blood samples were taken immediately before and 24h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels ofisolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS dataanalysis tool predicted 29 different pathways and processes that were largely grouped into cellsurface receptor signaling, cancer‐related pathways, the majority of which were previouslyassociated with fucoidans. However, this analysis also identified nine pathways and processes thathave not been associated with fucoidans before. Overall, this study illustrates that even a single doseof fucoidans has the potential to affect the expression of genes related to fundamental cellularprocesses. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells,inflammation, and neurological function.

Item Type:	Article
Authors/Creators:	Guven, N and Spring, KJ and Holmes, S and Ahuja, K and Eri, R and Park, AY and Fitton, JH
Keywords:	fucoidan, miRNA, clinical study
Journal or Publication Title:	Marine Drugs
Publisher:	M D P I AG
ISSN:	1660-3397
DOI / ID Number:	https://doi.org/10.3390/md18030143
Copyright Information:	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Related URLs:	Google Scholar: Guven, N UTAS Profile: Guven, N UTAS Profile: Holmes, S Google Scholar: Ahuja, K UTAS Profile: Ahuja, K Google Scholar: Eri, R UTAS Profile: Eri, R
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