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Abstract

This study examines the associations between medication adherence and burden, and health-related quality of life (HRQOL) in predialysis chronic kidney disease (CKD). A prospective study targeting adults with advanced CKD (estimated glomerular filtration rate (eGFR) 2) and not receiving renal replacement therapy was conducted in Tasmania, Australia. The actual medication burden was assessed using the 65-item Medication Regimen Complexity Index, whereas perceived burden was self-reported using a brief validated questionnaire. Medication adherence was assessed using a four-item Morisky-Green-Levine Scale (MGLS) and the Tool for Adherence Behaviour Screening (TABS). The Kidney Disease and Quality of Life Short-Form was used to assess HRQOL. Of 464 eligible adults, 101 participated in the baseline interview and 63 completed a follow-up interview at around 14 months. Participants were predominantly men (67%), with a mean age of 72 (SD 11) years and eGFR of 21 (SD 6) mL/min/1.73 m2. Overall, 43% and 60% of participants reported medication nonadherence based on MGLS and TABS, respectively. Higher perceived medication burden and desire for decision-making were associated with nonadherent behaviour. Poorer HRQOL was associated with higher regimen complexity, whereas nonadherence was associated with a decline in physical HRQOL over time. Medication nonadherence, driven by perceived medication burden, was prevalent in this cohort, and was associated with a decline in physical HRQOL over time.

Item Type:	Article
Authors/Creators:	Tesfaye, WH and McKercher, C and Peterson, GM and Castelino, RL and Jose, M and Zaidi, STR and Wimmer, BC
Keywords:	chronic kidney disease, medication adherence, health-related quality of life, medication regimen complexity index, medication burden
Journal or Publication Title:	International Journal of Environmental Research and Public Health
Publisher:	MDPI
ISSN:	1660-4601
DOI / ID Number:	https://doi.org/10.3390/ijerph17010371
Copyright Information:	Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Related URLs:	Google Scholar: McKercher, C UTAS Profile: Peterson, GM UTAS Profile: Castelino, RL Google Scholar: Jose, M UTAS Profile: Jose, M Google Scholar: Zaidi, STR UTAS Profile: Zaidi, STR UTAS Profile: Wimmer, BC
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