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The development and validation of a human screening model of tobacco abstinence

Grabski, M, Curran, HV, Nutt, DJ, Husbands, SM, Ferguson, SG ORCID: 0000-0001-7378-3497 and Munafo, MR 2020 , 'The development and validation of a human screening model of tobacco abstinence' , Drug and Alcohol Dependence, vol. 206 , pp. 1-7 , doi:

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Introduction: Given the low efficacy of smoking cessation methods, an experimental medicine model indicatingsmoking abstinence would be of great benefit to the development of new treatments. Hence the sensitivity ofcognitive tasks and ambulatory craving measures to smoking abstinence were investigated.Methods: Cognitive tasks and ambulatory ratings of craving were assessed for sensitivity to acute abstinence(experiment 1), and nicotine replacement therapy administration (NRT) (experiment 2).Results: In experiment 1 go/no-go performance was improved (Mean Difference [MD] -0.99, 95% CI: −1.90 to−0.08) and craving was lower (Regression Coefficient [RC] −33.39, 95% CI: -39.96 to -26.82) in satiatedcompared with abstinent smokers. There was no clear evidence that N-back (MD 0.64, 95% CI: −0.42 to 2.51),delay discounting (MD 0.01, 95% CI: 0.001 to 0.005) or dot probe performance (MD 0.61, 95% CI: −0.87 to1.54) were sensitive to acute abstinence. In experiment 2 go/no-go performance was improved (MD 1.12, 95%CI: 0.16–2.08) and craving was lower (RC −18.59, 95% CI: −24.63 to −12.55) smokers abstinent overnightreceiving NRT compared with placebo. There was no clear evidence that N-back (MD −0.25, 95% CI: −1.45 to0.94), delay discounting (MD 0.01, 95% CI: -0.002 to 0.004) or dot probe performance (MD −0.49, 95% CI:−1.61 to −0.64) were sensitive to NRT.Conclusions: Findings from two experiments converge to suggest that abstinence in smokers reliably increases ambulatory craving assessments and, to a lesser extent, decreases go/no-go task performance. These findings can beutilized in the development of an experimental medicine model to test novel treatments for smoking cessation.

Item Type: Article
Authors/Creators:Grabski, M and Curran, HV and Nutt, DJ and Husbands, SM and Ferguson, SG and Munafo, MR
Keywords: tobacco withdrawal, tobacco abstinence, cognitive performance, ecological momentary assessment, smoking cessation, experimental medicine model
Journal or Publication Title: Drug and Alcohol Dependence
Publisher: Elsevier Sci Ireland Ltd
ISSN: 0376-8716
DOI / ID Number:
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© 2019 Published by Elsevier B.V.

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