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Prevalence of comorbid substance use in major depressive disorder in community and clinical settings, 1990–2019: systematic review and meta-analysis

Hunt, GE, Malhi, GS, Lai, HMX and Cleary, M ORCID: 0000-0002-1453-4850 2020 , 'Prevalence of comorbid substance use in major depressive disorder in community and clinical settings, 1990–2019: systematic review and meta-analysis' , Journal of Affective Disorders, vol. 266 , pp. 288-304 , doi:

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Background: Comorbidity between Substance Use Disorders (SUDs) and major depression is highly prevalent.This systematic review and meta-analysis aimed to estimate the prevalence of SUDs in subjects diagnosed with amajor depressive disorder (MDD) in community, inpatient and outpatient settings.Methods: A comprehensive literature search of Medline, EMBASE, PsycINFO and CINAHL databases was conductedfrom 1990 to 2019. Prevalence of co-morbid SUDs and MDD were extracted and odds ratios (ORs) werecalculated using random effects meta-analysis.Results: There were 48 articles identified by electronic searches with a total sample size of 348,550 subjects thatyielded 14 unique epidemiological studies, 2 national case registry studies, 7 large cohort studies and 20 clinicalstudies using in- or out-patients. The prevalence of any SUD in individuals with MDD was 0.250. Maximumprevalence was found with alcohol use disorder (0.208), followed by illicit drug use disorder (0.118) andcannabis use disorder (0.117). Meta-analysis showed the pooled variance of any AUD in men with MDD was36%, which was significantly higher than that for females with MDD (19%, OR 2.628 95% CI 2.502, 2.760).Conclusions: Few studies were published over the last decade so current prevalence rates of SUD in MDD areneeded. Meta-analysis revealed that SUDs in MDD are highly prevalent and rates have not changed over time.The persistently high prevalence suggests there is an urgent need for more informative studies to help developbetter prevention and treatment options for reducing prevalence of SUDs in persons with major depression andco-morbid disorders.

Item Type: Article
Authors/Creators:Hunt, GE and Malhi, GS and Lai, HMX and Cleary, M
Keywords: major depression, prevalence, co-morbidity, substance use disorders, meta-analysis
Journal or Publication Title: Journal of Affective Disorders
Publisher: Elsevier Science Bv
ISSN: 0165-0327
DOI / ID Number:
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© 2020 Elsevier B.V. All rights reserved.

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