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Early life exposure to coal mine fire and tobacco smoke affect subclinical vascular function

Zhao, B, Johnston, FH ORCID: 0000-0002-5150-8678, O'Sullivan, T, Williamson, G ORCID: 0000-0002-3469-7550, Melody, S ORCID: 0000-0002-6692-739X, Dalton, M, Venn, A ORCID: 0000-0001-7090-1398 and Negishi, K ORCID: 0000-0002-9086-2565 2019 , 'Early life exposure to coal mine fire and tobacco smoke affect subclinical vascular function' , Archives of Disease in Childhood , pp. 1-6 , doi: 10.1136/archdischild-2019-317528.

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Abstract

Objective: To evaluate whether vascular health in young children was associated with exposure to a 6-week episode of coal mine fire smoke or environmental tobacco smoke (ETS) in a retrospective cohort study.Methods: Three years after a coal mine fire in Victoria, Australia, we investigated the vascular health of children either in utero (n = 75) or aged 2.5) exposures were estimated based on their daily locations throughout the fire period. Multivariable linear regression models were used to test for associations between the fire-related PM2.5 and outcomes adjusted for relevant covariates including ETS.Results: In the postnatal-exposure group, each 10 µg/m3 increase in mean PM2.5 level was independently positively associated with PWV (β = 0.116, p = 0.028). When these two groups were combined, there was an association between mean PM2.5 and increased PWV in those children who had ETS exposure (β = 0.148, p = 0.033) or whose mothers smoked (β = 0.151, p = 0.011), but not in those not exposed to ETS or maternal smoking.Conclusions: Three years after a coal mine fire, infants aged up to 2 years at the time of exposure have increases in vascular stiffness. Although no adverse effects were observed in the in uterus exposure group, further follow-up study is needed to elucidate the long-term effects of coal mine fire smoke exposure.

Item Type: Article
Authors/Creators:Zhao, B and Johnston, FH and O'Sullivan, T and Williamson, G and Melody, S and Dalton, M and Venn, A and Negishi, K
Keywords: smoke, tobacco, pollution, child health, vascular
Journal or Publication Title: Archives of Disease in Childhood
Publisher: B M J Publishing Group
ISSN: 0003-9888
DOI / ID Number: 10.1136/archdischild-2019-317528
Copyright Information:

© Author(s) (or their employer(s)) 2019.

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