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Measuring the interaction between the macro- and micro-vasculature


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Climie, RE, Gallo, A, Picone, DS ORCID: 0000-0002-4760-1634, Di Lascio, N, van Sloten, TT, Guala, A, Mayer, CC, Hametner, B and Bruno, RM 2019 , 'Measuring the interaction between the macro- and micro-vasculature' , Frontiers in Cardiovascular Medicine, vol. 6 , pp. 1-15 , doi: 10.3389/fcvm.2019.00169.

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Structural and functional dysfunction in both the macro- and microvasculature area feature of essential hypertension. In a healthy cardiovascular system, the elasticproperties of the large arteries ensure that pulsations in pressure and flow generated bycyclic left ventricular contraction are dampened, so that less pulsatile pressure and floware delivered at the microvascular level. However, in response to aging, hypertension,and other disease states, arterial stiffening limits the buffering capacity of the elasticarteries, thus exposing the microvasculature to increased pulsatile stress. This is thoughtto be particularly pertinent to high flow/low resistance organs such as the brain andkidney, which may be sensitive to excess pressure and flow pulsatility, damaging capillarynetworks, and resulting in target organ damage. In this review, we describe the clinicalrelevance of the pulsatile interaction between the macro- and microvasculature andsummarize current methods for measuring the transmission of pulsatility between thetwo sites.

Item Type: Article
Authors/Creators:Climie, RE and Gallo, A and Picone, DS and Di Lascio, N and van Sloten, TT and Guala, A and Mayer, CC and Hametner, B and Bruno, RM
Keywords: methods, microvascular, macrovascular, wave intensity analysis, brain, kidney, retina
Journal or Publication Title: Frontiers in Cardiovascular Medicine
Publisher: Frontiers Research Foundation
ISSN: 2297-055X
DOI / ID Number: 10.3389/fcvm.2019.00169
Copyright Information:

Copyright © 2019 Climie, Gallo, Picone, Di Lascio, van Sloten, Guala, Mayer, Hametner and Bruno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution orreproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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