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Inorganic particulate matter modulates non-typeable Haemophilus influenzae growth: a link between chronic bacterial infection and geogenic particles

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Williams, LJ, Tristram, SG ORCID: 0000-0002-8485-0322 and Zosky, GR ORCID: 0000-0001-9039-0302 2019 , 'Inorganic particulate matter modulates non-typeable Haemophilus influenzae growth: a link between chronic bacterial infection and geogenic particles' , Environmental Geochemistry and Health , pp. 1-9 , doi: 10.1007/s10653-019-00492-3.

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Abstract

Australian Aboriginal populations have unacceptably high rates of bronchiectasis. This disease burden is associated with high rates of detection of pathogenic bacteria, particularly non-typeable Haemophilus influenzae (NTHi). While there is evidence to suggest that exposure to inorganic particulate matter (PM) is associated with worse respiratory infections, no studies have considered the direct effect of this PM on bacterial growth. Nine clinical isolates of pathogenic NTHi were used for this study. Isolates were exposed to two common iron oxides, haematite (Fe2O3) or magnetite (Fe3O4), or quartz (SiO2), as the main constituents of environmental inorganic PM. NTHi isolates were exposed to PM with varying levels of heme to identify whether the response to PM was altered by iron availability. The maximal rate of growth and maximum supported growth were assessed. We observed that inorganic PM was able to modify the maximal growth of selected NTHi isolates. Magnetite and quartz were able to increase maximal growth, while haematite could both increase and suppress the maximal growth. However, these effects varied depending on iron availability and on the bacterial isolate. Our data suggest that inorganic PM may directly alter the growth of pathogenic NTHi. This observation may partly explain the link between exposure to high levels of crustal PM and chronic bacterial infection in Australian Aboriginals.

Item Type: Article
Authors/Creators:Williams, LJ and Tristram, SG and Zosky, GR
Keywords: particulate matter, iron oxide, Haemophilus influenzae, bacterial growth, Aboriginal children, bronchiectasis, heme, iron, lung infection
Journal or Publication Title: Environmental Geochemistry and Health
Publisher: Kluwer Academic Publ
ISSN: 0269-4042
DOI / ID Number: 10.1007/s10653-019-00492-3
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Copyright 2019 Springer Nature B.V.

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