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Abstract

Increased inflammation associated with leakygut is a major risk factor for morbidity and mortality inolder adults; however, successful preventive and therapeutic strategies against these conditions are not available. Inthis study, we demonstrate that a human-origin Lactobacillus paracasei D3-5 strain (D3-5), even in the non-viableform, extends life span of Caenorhabditis elegans. Inaddition, feeding of heat-killed D3-5 to old mice (> 79weeks) prevents high- fat diet-induced metabolic dysfunctions, decreases leaky gut and inflammation, and improves physical and cognitive functions. D3-5 feedingsignificantly increases mucin production, andproportionately, the abundance of mucin-degrading bacteria Akkermansia muciniphila also increases. Mechanistically, we show that the lipoteichoic acid (LTA), a cellwall component of D3-5, enhances mucin (Muc2) expression by modulating TLR-2/p38-MAPK/NF-kB pathway,which in turn reduces age-related leaky gut and inflammation. The findings indicate that the D3-5 and its LTAcan prevent/treat age-related leaky gut and inflammation.

Item Type:	Article
Authors/Creators:	Wang, S and Ahmadi, S and Nagpal, R and Jain, S and Mishra, SP and Kavanagh, K and Zhu, X and Wang, Z and McClain, DA and Kritchevsky, SB and Kitzman, DW and Yadav, H
Keywords:	aging, cell wall, cognition, goblet cell, inflammation, leaky gut, lipoteichoic acid, metabolism, mucin, probiotics, physical function
Journal or Publication Title:	GeroScience
Publisher:	Springer International Publishing
ISSN:	2509-2715
DOI / ID Number:	https://doi.org/10.1007/s11357-019-00137-4
Copyright Information:	Copyright 2019 American Aging Association
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