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Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific

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Mulholland, CV, Shockey, AC, Aung, HL, Cursons, RT, O'Toole, RF ORCID: 0000-0002-4579-4479, Gautam, SS, Brites, D, Gagneux, S, Roberts, SA, Karalus, N, Cook, GM, Pepperell, CS and Arcus, VL 2019 , 'Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific' , Frontiers in Microbiology, vol. 10 , pp. 1-13 , doi: 10.3389/fmicb.2019.02778.

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Abstract

Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whosepopulation structure has largely been shaped by the activities of its obligate human host.Oceania was the last major global region to be reached by Europeans and is the lastregion for which the dispersal and evolution of Mtb remains largely unexplored. Here,we investigated the evolutionary history of the Euro-American L4.4 sublineage and itsdispersal to the South Pacific. Using a phylodynamics approach and a dataset of 236global Mtb L4.4 genomes we have traced the origins and dispersal of L4.4 strains toNew Zealand. These strains are predominantly found in indigenous Maori and Pacific ¯people and we identify a clade of European, likely French, origin that is prevalent inindigenous populations in both New Zealand and Canada. Molecular dating suggeststhe expansion of European trade networks in the early 19th century drove the dispersalof this clade to the South Pacific. We also identify historical and social factors withinthe region that have contributed to the local spread and expansion of these strains,including recent Pacific migrations to New Zealand and the rapid urbanization of Maori ¯in the 20th century. Our results offer new insight into the expansion and dispersal of Mtbin the South Pacific and provide a striking example of the role of historical Europeanmigrations in the global dispersal of Mtb.

Item Type: Article
Authors/Creators:Mulholland, CV and Shockey, AC and Aung, HL and Cursons, RT and O'Toole, RF and Gautam, SS and Brites, D and Gagneux, S and Roberts, SA and Karalus, N and Cook, GM and Pepperell, CS and Arcus, VL
Keywords: tuberculosis, pathogen, phylodynamics, phylogeography, indigenous people, Pacific, New Zealand
Journal or Publication Title: Frontiers in Microbiology
Publisher: Frontiers Research Foundation
ISSN: 1664-302X
DOI / ID Number: 10.3389/fmicb.2019.02778
Copyright Information:

Copyright © 2019 Mulholland, Shockey, Aung, Cursons, O’Toole, Gautam, Brites, Gagneux, Roberts, Karalus, Cook, Pepperell and Arcus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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