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Effect of phacoemulsification cataract surgery on intraocular pressure in early glaucoma: a prospective multi-site study

Qassim, A, Walland, MJ, Landers, J, Awadalla, M, Nguyen, T, Loh, J, Schulz, AM, Ridge, B, Galanopoulos, A, Agar, A, Hewitt, AW ORCID: 0000-0002-5123-5999, Graham, SL, Healey, PR, Casson, RJ and Craig, JE 2020 , 'Effect of phacoemulsification cataract surgery on intraocular pressure in early glaucoma: a prospective multi-site study' , Clinical and Experimental Ophthalmology , pp. 1-8 , doi: 10.1111/ceo.13724.

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Importance: Cataract and primary open-angle glaucoma (POAG) commonly co-exist, and cataract surgery is thought to reduce intraocular pressure (IOP), the major modifiable risk factor of POAG.Background: Previous studies exploring the effect of cataract surgery on IOP are limited by retrospective design, lack of a control group, medication use and washout and loss to follow up.Design: Prospective, multicentre, matched case-control Australian study.Participants: 171 eyes of 108 POAG patients who underwent cataract surgery, matched to 171 control eyes.Methods: Serial longitudinal IOP measurements were compared before and after cataract surgery, and relative to the controls. A mixed-effect model was used for the longitudinal data.Main Outcome Measures: Change in IOP.Results: The mean follow-up time was 4.8 (1.4) years. Cataract surgery reduced mean IOP by 2.22 mmHg (95% confidence interval: 1.93-2.52 mmHg, P P Conclusions and Relevance: Cataract surgery has a confirmed effect in reducing IOP in a "real world" setting of early glaucoma patients.

Item Type: Article
Authors/Creators:Qassim, A and Walland, MJ and Landers, J and Awadalla, M and Nguyen, T and Loh, J and Schulz, AM and Ridge, B and Galanopoulos, A and Agar, A and Hewitt, AW and Graham, SL and Healey, PR and Casson, RJ and Craig, JE
Keywords: biometry, cataract, cataract surgery, open-angle glaucoma, phacoemulsification
Journal or Publication Title: Clinical and Experimental Ophthalmology
Publisher: Blackwell Publishing Asia
ISSN: 1442-6404
DOI / ID Number: 10.1111/ceo.13724
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Copyright 2020 Royal Australian and New Zealand College of Ophthalmologists

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