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The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: a systematic review

Marx, W, Hockey, M, McGuinness, AJ, Lane, M, Christodoulou, J, van der Mei, I ORCID: 0000-0001-9009-7472, Berk, M, Dean, OM, Taylor, B, Broadley, S, Lechner-Scott, J, Jacka, FN, Lucas, RM and Ponsonby, A-L 2020 , 'The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: a systematic review' , Multiple Sclerosis and Related Disorders, vol. 37 , pp. 1-16 , doi: 10.1016/j.msard.2019.101486.

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Abstract

Background: Due to the considerable burden of multiple sclerosis (MS)-related symptoms and the need to identify effective interventions to prevent disease progression, various nutraceutical interventions have been trialed as adjunctive treatments. The aim of this review was to investigate the efficacy and safety of nutraceutical interventions for clinical and biological outcomes in people with MS.Methods: In accordance with PRISMA reporting guidelines, a systematic literature search was conducted using three electronic literature databases. Risk of bias was assessed using the Jadad scale.Results: Thirty-seven randomized controlled trials, investigating fourteen nutraceuticals, were included in the review. Trials that investigated alpha lipoic acid (n = 4/6), ginkgo biloba (n = 3/5), vitamin A (n = 2/2), biotin (n = 1/2), carnitine (n = 1/2), green tea (n = 1/2), coenzyme Q10 (n = 1/1), probiotics (n = 1/1), curcumin (n = 1/1), Andrographis paniculata (n = 1/1), ginseng (n = 1/1), and lemon verbena (n = 1/1) were reported to improve biological (e.g. MRI brain volume change, antioxidant capacity) and/or clinical (e.g. fatigue, depression, Expanded Disability Status Scale) outcomes in multiple sclerosis compared to control. However, most trials were relatively small (average study sample size across included studies, n = 55) and there were few replicate studies per nutraceutical to validate the reported results. Furthermore, some nutraceuticals (e.g. green tea and inosine) should be used with caution due to reported adverse events. Risk of bias across most studies was low, with 31 studies receiving a score between 4 and 5 (out of 5) on the Jadad Scale.Conclusion: The existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS. However, sufficiently powered long-term trials are required to expand the currently limited literature and to investigate unexplored nutraceuticals that may target relevant pathways involved in MS such as the gut microbiome and mitochondrial dysfunction.

Item Type: Article
Authors/Creators:Marx, W and Hockey, M and McGuinness, AJ and Lane, M and Christodoulou, J and van der Mei, I and Berk, M and Dean, OM and Taylor, B and Broadley, S and Lechner-Scott, J and Jacka, FN and Lucas, RM and Ponsonby, A-L
Keywords: dietary supplement, multiple sclerosis, nutraceutical, vitamin
Journal or Publication Title: Multiple Sclerosis and Related Disorders
Publisher: Elsevier BV
ISSN: 2211-0348
DOI / ID Number: 10.1016/j.msard.2019.101486
Copyright Information:

Copyright 2019 Elsevier B.V.

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