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Maternal exposure to ambient air pollution and pregnancy complications in Victoria, Australia

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Melody, SM ORCID: 0000-0002-6692-739X, Wills, K ORCID: 0000-0003-3897-2908, Knibbs, LD, Ford, J, Venn, A ORCID: 0000-0001-7090-1398 and Johnston, F ORCID: 0000-0002-5150-8678 2020 , 'Maternal exposure to ambient air pollution and pregnancy complications in Victoria, Australia' , International Journal of Environmental Research and Public Health, vol. 17, no. 7 , pp. 1-12 , doi: 10.3390/ijerph17072572.

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Abstract

The relationship between maternal exposure to ambient air pollution and pregnancy complications is not well characterized. We aimed to explore the relationship between maternal exposure to ambient nitrogen dioxide (NO2) and fine particulate matter (PM2.5) and hypertensive disorders of pregnancy, gestational diabetes mellitus (GDM) and placental abruption. Using administrative data, we defined a state-wide cohort of singleton pregnancies born between 1 March 2012 and 31 December 2015 in Victoria, Australia. Annual average NO2 and PM2.5 was assigned to maternal residence at the time of birth. 285,594 singleton pregnancies were included. An IQR increase in NO2 (3.9 ppb) was associated with reduced likelihood of hypertensive disorders of pregnancy (RR 0.89; 95%CI 0.86, 0.91), GDM (RR 0.92; 95%CI 0.90, 0.94) and placental abruption (RR 0.81; 95%CI 0.69, 0.95). Mixed observations and smaller effect sizes were observed for IQR increases in PM2.5 (1.3 µg/m3) and pregnancy complications; reduced likelihood of hypertensive disorders of pregnancy (RR 0.95; 95%CI 0.93, 0.97), increased likelihood of GDM (RR 1.02; 95%CI 1.00, 1.03) and no relationship for placental abruption. In this exploratory study using an annual metric of exposure, findings were largely inconsistent with a priori expectations and further research involving temporally resolved exposure estimates are required.

Item Type: Article
Authors/Creators:Melody, SM and Wills, K and Knibbs, LD and Ford, J and Venn, A and Johnston, F
Keywords: air pollution, pregnancy, gestational diabetes mellitus, preeclampsia, placental abruption
Journal or Publication Title: International Journal of Environmental Research and Public Health
Publisher: M D P I AG
ISSN: 1661-7827
DOI / ID Number: 10.3390/ijerph17072572
Copyright Information:

Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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