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Neural remodelling in spiny lobster larvae is characterized by broad neuropeptide suppression

Hyde, CJ, Nguyen, T, Fitzgibbon, QP ORCID: 0000-0002-1104-3052, Elizur, A, Smith, GG ORCID: 0000-0002-8677-1230 and Ventura, T 2020 , 'Neural remodelling in spiny lobster larvae is characterized by broad neuropeptide suppression' , General and Comparative Endocrinology, vol. 294 , pp. 1-10 , doi: 10.1016/j.ygcen.2020.113496.

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Abstract

Neuropeptides are ancient endocrine components which have evolved to regulate many aspects of biology across the animal kingdom including behaviour, development and metabolism. To supplement current knowledge, we have utilized a transcriptome series describing larval development in the ornate spiny lobster, Panulirus ornatus. The biology of this animal has been leveraged to provide insights into the roles of molting, metamorphosis and metabolism across the neuropeptide family. We report an extensive list of neuropeptides across three distinct life phases of the animal. We show distinct groups of neuropeptides with differential expression between larval phases, indicating phase-specific roles for these peptides. For selected neuropeptides, we describe and discuss expression profiles throughout larval development and report predicted peptide cleavage sites and mature peptide sequences. We also report the neuropeptide nesfatin for the first time in a crustacean, and report secondary peptide products with a level of evolutionary conservation similar to the conventional mature peptide nesfatin-1, indicating a conserved role in these secondary products which are widely regarded as biologically inactive. In addition, we report a trend of downregulation in the neuropeptides as the animal undergoes extensive neural remodelling in fulfillment of metamorphosis. We suggest that this downregulation in neuropeptides relates to the brief, yet dramatic changes in morphology experienced by the central nervous system in the process of metamorphosis.

Item Type: Article
Authors/Creators:Hyde, CJ and Nguyen, T and Fitzgibbon, QP and Elizur, A and Smith, GG and Ventura, T
Keywords: Phyllosoma, neural remodelling, metamorphosis, Panulirus ornatus, crustacean, transcriptome, brain, regulation, molt
Journal or Publication Title: General and Comparative Endocrinology
Publisher: Academic Press Inc Elsevier Science
ISSN: 0016-6480
DOI / ID Number: 10.1016/j.ygcen.2020.113496
Copyright Information:

Copyright 2020 Elsevier Inc.

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