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Constitutive melanin density is associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults

Thompson, MJW, Jones, G ORCID: 0000-0002-9814-0006, Balogun, S ORCID: 0000-0001-6415-5536 and Aitken, DA ORCID: 0000-0001-5685-7634 2020 , 'Constitutive melanin density is associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults' , Osteoporosis International , pp. 1-8 , doi: 10.1007/s00198-020-05304-4.

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Abstract

Summary: Higher cutaneous melanin reduces vitamin D3 production. This may increase fracture risk. We found that cutaneous melanin density was associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults. Melanin density either acts as a surrogate marker or its relationship with fracture changes with time. Introduction: Higher cutaneous melanin reduces vitamin D3 production. This may impact lifetime vitamin D status and increase fracture risk. This study aimed to describe the relationship between spectrophotometrically determined constitutive melanin density, prevalent and incident fractures in a cohort of exclusively older Caucasian adults. Methods: 1072 community-dwelling adults aged 50-80 years had constitutive melanin density quantified using spectrophotometry. Participants were followed up at 2.5 (n = 879), 5 (n = 767), and 10 (n = 571) years after the baseline assessment. Prevalence and number of symptomatic fractures were assessed by questionnaire. Results: Higher melanin density was independently associated with greater prevalence of any fracture (RR 1.08, p = 0.03), vertebral fracture (RR 1.41, p = 0.04) and major fracture (RR 1.12, p = 0.04) and the number of fractures (RR 1.09, p = 0.04) and vertebral fractures (RR 1.47, p = 0.04) in cross-sectional analysis. At the 2.5-year follow-up, higher melanin density was associated with incident fractures (RR 1.42, p = 0.01) and major fractures (RR 1.81, p = 0.01) and the number of incident fractures (RR 1.39, p = 0.02) and major fractures (RR 2.14, p = 0.01). The relationship between melanin density and incident fracture attenuated as the duration of follow-up increased and was not significant at the 5- or 10-year follow-up. Conclusions: Constitutive melanin density was associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults. This suggests melanin density either acts as a surrogate marker for an unmeasured fracture risk factor or the relationship between melanin density and fracture changes with time.

Item Type: Article
Authors/Creators:Thompson, MJW and Jones, G and Balogun, S and Aitken, DA
Keywords: fractures, melanin density, skin pigmentation
Journal or Publication Title: Osteoporosis International
Publisher: Springer-Verlag London Ltd
ISSN: 0937-941X
DOI / ID Number: 10.1007/s00198-020-05304-4
Copyright Information:

Copyright International Osteoporosis Foundation and National Osteoporosis Foundation 2020

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