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Validation of 0-10 MS symptom scores in the Australian multiple sclerosis longitudinal study

Zhang, Y ORCID: 0000-0001-9126-4922, Taylor, BV, Simpson Jr, S ORCID: 0000-0001-6521-3056, Blizzard, L ORCID: 0000-0002-9541-6943, Palmer, AJ ORCID: 0000-0002-9703-7891 and van der Mei, I ORCID: 0000-0001-9009-7472 2020 , 'Validation of 0-10 MS symptom scores in the Australian multiple sclerosis longitudinal study' , Multiple Sclerosis and Related Disorders, vol. 39 , pp. 1-8 , doi: 10.1016/j.msard.2019.101895.

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Background: Multiple sclerosis (MS) symptom measurements often use multiple-item scales per symptom, creating a high burden when multiple symptoms are assessed. We aimed to examine the validity, stability and responsiveness of single-item 0-10 numeric rating MS Symptom Scores (MSSymS). Methods: The study included 1,985 participants from the Australian Multiple Sclerosis Longitudinal Study. Thirteen MS symptoms were assessed using the MSSymS, of which we were able to validate six (walking difficulties, fatigue, pain, feelings of anxiety, feelings of depression and vision problems). Comparison measures included Patient Determined Disease Steps (PDDS), Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), and Assessment of Quality of Life (AQoL). We used spearman rank correlation for concurrent validity, linear regression for predictive validity, intra-class correlations for stability, and percentage change for responsiveness. Results: We found high correlations between walking difficulties and PDDS (r = 0.82), pain and AQoL-pain (r = 0.77), fatigue and FSS (r = 0.72); moderate correlations between feelings of anxiety and HADS-Anxiety (r = 0.68), feelings of depression and HADS-Depression (r = 0.63); and low correlation between vision and AQoL-vision (r = 0.43) For predictive validity, the graphs with quality of life were largely overlapping and the R2 of the regression lines were generally similar. The stability and responsiveness of the MSSymS were adequate. Conclusion: The six assessed symptoms of the MSSymS performed equally well compared to validated comparison measures in terms of concurrent and predictive validity, temporal stability and responsiveness.

Item Type: Article
Authors/Creators:Zhang, Y and Taylor, BV and Simpson Jr, S and Blizzard, L and Palmer, AJ and van der Mei, I
Keywords: multiple sclerosis, symptom measure, numeric rating scale, validity, responsiveness, MSSymS
Journal or Publication Title: Multiple Sclerosis and Related Disorders
Publisher: Elsevier BV
ISSN: 2211-0348
DOI / ID Number: 10.1016/j.msard.2019.101895
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© 2019 Elsevier B.V. All rights reserved.

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