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Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

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Erdrich, S, Hawrelak, JA ORCID: 0000-0002-7436-9666, Myers, SP and Harnett, JE 2020 , 'Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review' , BMC Musculoskeletal Disorders, vol. 21, no. 1 , pp. 1-12 , doi: 10.1186/s12891-020-03201-9.

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Abstract

Background: The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations inthe composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however,this association is poorly understood in fibromyalgia.Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in peoplewith fibromyalgia.Methods: A systematic review of published original research reporting on the gastrointestinal microbiota and itsbiomarkers in adults with a diagnosis of fibromyalgia was undertaken.Results: From 4771 studies, 11 met our inclusion criteria and were separated into four main groups: papersreporting Helicobacter pylori; other gut bacterial markers; metabolomics and other biomarkers, which includedintestinal permeability and small intestinal bacterial overgrowth.Conclusion: The results suggest there is a paucity of quality research in this area, with indications that the gutmicrobiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Furtherinvestigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted.

Item Type: Article
Authors/Creators:Erdrich, S and Hawrelak, JA and Myers, SP and Harnett, JE
Keywords: fibromyalgia, fibromyalgia syndrome, gastrointestinal microbiome, biomarkers, systematic review
Journal or Publication Title: BMC Musculoskeletal Disorders
Publisher: Biomed Central Ltd
ISSN: 1471-2474
DOI / ID Number: 10.1186/s12891-020-03201-9
Copyright Information:

Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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