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Anti-heartburn effects of sugar cane flour: A double-blind, randomized, placebo-controlled study

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Beckett, JM ORCID: 0000-0002-2911-0313, Singh, NK, Phillips, J, Kalpurath, K, Taylor, K, Stanley, RA ORCID: 0000-0002-2279-5022 and Eri, RD ORCID: 0000-0003-1688-8043 2020 , 'Anti-heartburn effects of sugar cane flour: A double-blind, randomized, placebo-controlled study' , Nutrients, vol. 12 , pp. 1-9 , doi: 10.3390/nu12061813.

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Abstract

Gastroesophageal reflux disease (GERD) affects approximately 20% of Australians. Patientssuffer a burning sensation known as heartburn due to the movement of acidic stomach content into theesophagus. There is anecdotal evidence of the effectiveness of prebiotic sugarcane flour in controllingsymptoms of GERD. This pilot study aimed to investigate the effectiveness of a prebiotic sugarcaneflour in alleviating symptoms in medically-diagnosed GERD patients. This pilot study was a singlecenter, double-blinded, placebo-controlled randomized trial conducted on 43 eligible participants.The intervention group (n = 22) were randomized to receive 3 g of sugarcane flour per day, and thecontrol group (n = 21) received 3 g of cellulose placebo per day. Symptoms of gastroesophageal refluxdisease were assessed before and after three weeks treatment using the validated GastroesophagealReflux Disease-Health Related Quality of Life questionnaire (GERD-HRQL). After three weeks therewere significant differences in symptoms for heartburn, regurgitation, and total symptoms scores(pp = 0.015) and total symptomscores (2.9; 95% CI 0.26 to 5.7; p = 0.033). In contrast, there were significant reductions in heartburn(mean decrease −2.2; 95% CI −4.2 to −0.14; p = 0.037) and total symptom scores (−3.7; 95% CI −7.2 to−0.11; p = 0.044) in the intervention group. This pilot study has shown significant positive effectsof sugarcane flour in the reduction of GERD symptoms, and a larger randomized controlled trialis warranted.

Item Type: Article
Authors/Creators:Beckett, JM and Singh, NK and Phillips, J and Kalpurath, K and Taylor, K and Stanley, RA and Eri, RD
Keywords: gastroesophageal reflux disease, heartburn, regurgitation, sugarcane flour, dietary fiber
Journal or Publication Title: Nutrients
Publisher: M D P I AG
ISSN: 2072-6643
DOI / ID Number: 10.3390/nu12061813
Copyright Information:

Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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