Full text not available from this repository.

Abstract

Objectives: To investigate the cross-sectional associations between suprapatellar pouch effusion-synovitis and serum levels of cartilage oligomeric matrix protein (COMP), high sensitivity C-reaction protein (hs-CRP), knee symptom, and structural changes in patients with symptomatic knee osteoarthritis (OA).Method: A total of 173 subjects were included. The osteophytes, joint space narrowing (JSN), and radiographic severity of OA were determined using X-ray. Cartilage defects, bone marrow lesions (BMLs), and suprapatellar pouch effusion-synovitis were assessed using magnetic resonance imaging. Serum levels of COMP and hs-CRP were measured by enzyme-linked immunosorbent assay. The knee joint symptom was self-reported using visual analogue scale.Results: In this OA cohort, after adjustment for age, sex, and BMI, the presence of pathological effusion-synovitis was associated with serum levels of COMP (β: 30.98, P = 0.018), and suprapatellar pouch effusion-synovitis maximum areas were associated with serum hs-CRP levels. Both suprapatellar pouch effusion-synovitis maximum area and grade were associated with osteophytes and Kellgren-Lawrence scores (ORs: 1.29-1.54, all P P P Conclusions: Suprapatellar pouch effusion-synovitis was associated with serum levels of COMP as well as hs-CRP and knee structural abnormalities in patients with knee OA. These suggested that effusion-synovitis may play a role in knee OA.

Item Type:	Article
Authors/Creators:	Yang, X and Ruan, G and Xu, J and Zheng, S and Wang, K and Ding, C
Keywords:	bone marrow, cartilage, clinical aspects, knee joint, osteoarthritis, synovitis
Journal or Publication Title:	Clinical Rheumatology
Publisher:	Springer-Verlag
ISSN:	0770-3198
DOI / ID Number:	https://doi.org/10.1007/s10067-019-04905-7
Copyright Information:	Copyright International League of Associations for Rheumatology (ILAR) 2020
Related URLs:	Google Scholar: Ding, C UTAS Profile: Ding, C
Item Statistics:	View statistics for this item

Actions (login required)

Item Control Page