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Associations between suprapatellar pouch effusion-synovitis, serum cartilage oligomeric matrix protein, high sensitivity C-reaction protein, knee symptom, and joint structural changes in patients with knee osteoarthritis

Yang, X, Ruan, G, Xu, J, Zheng, S ORCID: 0000-0003-3552-1247, Wang, K and Ding, C ORCID: 0000-0002-9479-730X 2020 , 'Associations between suprapatellar pouch effusion-synovitis, serum cartilage oligomeric matrix protein, high sensitivity C-reaction protein, knee symptom, and joint structural changes in patients with knee osteoarthritis' , Clinical Rheumatology, vol. 39, no. 5 , pp. 1663-1670 , doi: 10.1007/s10067-019-04905-7.

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Abstract

Objectives: To investigate the cross-sectional associations between suprapatellar pouch effusion-synovitis and serum levels of cartilage oligomeric matrix protein (COMP), high sensitivity C-reaction protein (hs-CRP), knee symptom, and structural changes in patients with symptomatic knee osteoarthritis (OA).Method: A total of 173 subjects were included. The osteophytes, joint space narrowing (JSN), and radiographic severity of OA were determined using X-ray. Cartilage defects, bone marrow lesions (BMLs), and suprapatellar pouch effusion-synovitis were assessed using magnetic resonance imaging. Serum levels of COMP and hs-CRP were measured by enzyme-linked immunosorbent assay. The knee joint symptom was self-reported using visual analogue scale.Results: In this OA cohort, after adjustment for age, sex, and BMI, the presence of pathological effusion-synovitis was associated with serum levels of COMP (β: 30.98, P = 0.018), and suprapatellar pouch effusion-synovitis maximum areas were associated with serum hs-CRP levels. Both suprapatellar pouch effusion-synovitis maximum area and grade were associated with osteophytes and Kellgren-Lawrence scores (ORs: 1.29-1.54, all P P P Conclusions: Suprapatellar pouch effusion-synovitis was associated with serum levels of COMP as well as hs-CRP and knee structural abnormalities in patients with knee OA. These suggested that effusion-synovitis may play a role in knee OA.

Item Type: Article
Authors/Creators:Yang, X and Ruan, G and Xu, J and Zheng, S and Wang, K and Ding, C
Keywords: bone marrow, cartilage, clinical aspects, knee joint, osteoarthritis, synovitis
Journal or Publication Title: Clinical Rheumatology
Publisher: Springer-Verlag
ISSN: 0770-3198
DOI / ID Number: 10.1007/s10067-019-04905-7
Copyright Information:

Copyright International League of Associations for Rheumatology (ILAR) 2020

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